Development of a New Prognostic Assessment Tool for Postoperative Myocardial Injury : the TROPUTILE Score. A Non-interventional Prospective Study
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Perioperative Complication
- Sponsor
- University Hospital, Brest
- Enrollment
- 1600
- Locations
- 2
- Primary Endpoint
- Postoperative MINS incidence
- Status
- Recruiting
- Last Updated
- last year
Overview
Brief Summary
Myocardial injury after noncardiac surgery (MINS) is common, silent, and strongly associated with morbi-mortality.
There are some evidences in the littérature showing that troponin elevation pre and/or postoperatively and surgical Apgar score are strongly and independently associated with postoperative morbi-mortality.
In this cohort study of orthopedic surgery patients (> 50years), the aim is to determine MINS incidence and to assess wich peri-operative factors are associated with the occurrence of MINS. The final objective is to create a score to better identified the patients with a MINS and a poor outcome.
Investigators
Eligibility Criteria
Inclusion Criteria
- •\> 50 years
- •orthopedic surgery (hip, knee, spine)
- •written consent
Exclusion Criteria
- •no troponin measurement prior surgery
- •acute coronary syndrome
- •pulmonary embolism
- •refusing to participate
- •guardianship
Outcomes
Primary Outcomes
Postoperative MINS incidence
Time Frame: 3 days after surgery
Troponin elevation \> 5ng/l compared to previous measurement OR troponin elevation \> 65 ng/l
Secondary Outcomes
- Mortality rate(3 months)
- Number of Participants with myocardial infarction(3 months)
- Number of Participants with stroke(3 months)
- Number of Participants with an episode of acute pulmonary oedema(3 months)
- Number of Participants with coronary angioplasty(3 months)
- Number of Participants with transient stroke(3 months)
- Revised Cardiac Risk Index for Pre-Operative Risk (Lee score)(Inclusion)
- Metabolic Equivalent of Task (MET)(Inclusion)
- Number of Participants with cardiac arrest(3 months)