Myocardial Injury After Non-cardiac Surgery (MINS), Acute Kidney Injury (AKI) and Pulmonary Pathology in Patients Undergoing Acute Abdominal Surgery
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Abdomen, Acute
- Sponsor
- Nordsjaellands Hospital
- Enrollment
- 600
- Locations
- 1
- Primary Endpoint
- Acute kidney Injury
- Status
- Active, not recruiting
- Last Updated
- 2 years ago
Overview
Brief Summary
Explorative study to investigate potential predictors of myocardial injury, acute kidney injury and pulmonary disorder after acute high-risk abdominal surgery.
Detailed Description
The main issues are: * To investigate if coronary calcification predisposes the development of myocardial injury and causes an increased mortality rate. * To evaluate the predictive value of NT-pro-BNP in relation to the development of MINS and the mortality rate. * To evaluate the predictive value of different biomarkers of AKI in relation to which patients develop AKI. * To examine the proteins, exosomes and single cell RNA during acute kidney injury in order to describe the molecular processes in the kidney during AKI. * To examine whether a chest CT scan without contrast enhancement will change treatment decisions in the acute gastrointestinal patient compared with a chest x-ray.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Adults (≥18 years).
- •Patients included in the AHA regimen undergoing CT on suspicion acute high-risk abdominal disorder e.g.g bowel obstruction GI perforation or ischemia, and need of emergency abdominal surgery, either laparoscopic surgery or laparotomy.
- •Able to speak Danish. In case Danish was not spoken an interpreter was used to obtain the informed consent.
- •Able to give informed consent.
Exclusion Criteria
- •Patients who cannot give informed consent to participate in the study 15 minutes after receiving verbal information regarding the study.
- •Known chronic kidney disease requiring dialysis at the time of admission (only exclusion criteria for the part of the study relating to AKI).
- •Patients included in the AHA regimen, but conservative treatment is chosen (only exclusion criteria for the part of the study relating to MINS and AKI).
- •Patients not resident in Denmark.
- •Patients not able to give informed consent.
- •Patient not able to speak Danish and not enough time to obtain an interpreter.
Outcomes
Primary Outcomes
Acute kidney Injury
Time Frame: 30 days
According to KIDGO criteria
Proportion of patients with myocardial injury af non-cardiac surgery
Time Frame: 30 days
Troponin-I above specified level and dynamic changes
Mortality rate
Time Frame: 1 year
Postoperative mortality
Proportion of patients with pulmonary pathology
Time Frame: 1 day
Findings (including incidental) on a chest x-ray and chest CT scan without contrast enhancement
Proportion of patients with pulmonary complications
Time Frame: 30 days
Postoperative complications