Unraveling Perioperative Myocardial Injury

Active, not recruiting

• Conditions: Myocardial Injury; Myocardial Injury After Non-Cardiac Surgery

• Registration Number: NCT06728111
• Lead Sponsor: Erasmus Medical Center

Brief Summary

The aim of this study is to gain insight into the etiology of myocardial injury after non cardiac surgery. Furthermore, suspected etiologies were explored and hierarchically classified into most likely cause how this determines prognosis and what factors are associated with improved outcome.

Detailed Description

As above

Study Timeline

• Study Start: 2023-07-24
• Status Verified: 2024-12
• Study First Submitted: 2024-12-05
• Study First Submitted QC: 2024-12-05
• Last Update Submitted: 2024-12-05
• Study First Posted: 2024-12-11
• Last Update Posted: 2024-12-11
• Primary Completion: 2025-03-01
• Study Completion: 2027-03-01

Recruitment & Eligibility

• Status: ACTIVE_NOT_RECRUITING
• Sex: All
• Target Recruitment: 1114

Inclusion Criteria

• Age > 18 year of age
• Undergoing non-cardiac surgery in the Erasmus MC, with (high-sensitive) Troponin T > 50 ng/L measured in any of the first three days after surgery.

Exclusion Criteria

• Re-operations within the study period.
• Daycare surgery

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Main etiologies elevated troponin T	from enrollment	The primary endpoint is a description of the main etiologies found within patients with an elevated troponin T after non cardiac surgery.

Secondary Outcome Measures

Name	Time	Method
Differences in adjudication	from enrollment	Differences in the adjudication process between different doctors will be assessed according to intraclass coeficients and Fleisch Kappa

Trial Locations

Locations (1)

Erasmus Medical Center; 🇳🇱 Rotterdam, Netherlands