Measurement of Sarcopenia at Post-stroke Rehabilitation Outcome
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 70
- 试验地点
- 1
- 主要终点
- Change in K-MBI score from initial evaluation to the final evaluation
研究概览
简要总结
The purposes of this study are
- To explore effect of sarcopenia on recovery of post stroke hemiplegia
- To explore the effect of stroke on sarcopenia and relationship between the degree of sarcopenia and respiration and swallowing function
- To quantify and qualify post stroke loss of muscle mass
- To validity the use of echointensity and elastography in evaluation of sarcopenia.
By reaching the above list purposes, sarcopenia can be viewed as one of serious post stroke complications that is closely related to worth functional outcome, thereby emphasizing the importance of evaluation of sarcopenia as well as its prevention.
详细描述
Sarcopenia occurs frequently among old population. The changes can rather occur earlier after trauma or generalized illness. However, the nature of these sarcopenia is different from that of geriatric population. Post stroke sarcopenia is underestimated however reduction in the motor uni number begins within 4 hours post stroke and after 3 weeks, sarcopenia can be seen in both hemiplegia and normal side. This muscular weakness can hinder functional recovery process.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 20 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- 未提供
排除标准
- •for stroke patients
- •Patients who do not meet the above listed criteria
- •Patients with double hemiplegia
- •Patients with other systemic diseases that can affect loss of muscle mass or causr malnutrition. (Example : chronic inflammatory disease, autoimmune disease, chronic intestinalis, active tuberculosis, immunocompromised state, AIDS, malignancy, pregnancy, amputation, or operation.
- •Patients with joint contracture who are difficult to perform sonographic evaluation.
- •Traumatic brain injury patients.
- •Inclusion Criteria for normal subjects
- •Subjects who can walk independent without any difficult
- •Subjects without history of CNS or PNS lesion
- •MRS(Modified ranking scale) <=2
- •FAC(functional ambulation category) >=2
- •Exclusion Criteria for normal subjects
- •Patients with other systemic diseases that can affect loss of muscle mass or causr malnutrition. (Example : chronic inflammatory disease, autoimmune disease, chronic intestinalis, active tuberculosis, immunocompromised state, AIDS, malignancy, pregnancy, amputation, or operation.
结局指标
主要结局
Change in K-MBI score from initial evaluation to the final evaluation
时间窗: 8 weeks, 12 weeks, 16 weeks from the first onset of the stroke
次要结局
- Change in Motricity index from initial evaluation to the final evaluation(8 weeks, 12 weeks, 16 weeks from the first onset of the stroke)
- Change in MMSE from initial evaluation to the final evaluation(8 weeks, 12 weeks, 16 weeks from the first onset of the stroke)
- Change in Fatigue scale from initial evaluation to the final evaluation(8 weeks, 12 weeks, 16 weeks from the first onset of the stroke)
- Change in Functional Oral Intake Scale (FOIS) from initial evaluation to the final evaluation(8 weeks, 12 weeks, 16 weeks from the first onset of the stroke)
- Change in Berg balance scale from initial evaluation to the final evaluation(8 weeks, 12 weeks, 16 weeks from the first onset of the stroke)
研究者
Geun-Young Park
MD, PhD
Bucheon St. Mary's Hospital