The Effect of Exercise on Serum Levels of Collagen and Proteoglycan in Patients With Knee Osteoarthritis (EFEX-OA-01)

Not Applicable

Completed

• Conditions: Osteoarthritis, Knee
• Interventions: Other: Treadmill Running followed by ergometer cycling; Other: Ergometer Cycling followed by treadmill running; Other: Rest

• Registration Number: NCT04542655
• Lead Sponsor: Nordic Bioscience A/S

Brief Summary

Aim of EFEX-OA-01: To explore how running, cycling and resting acutely influence levels of collagen and proteoglycan in patients with osteoarthritis knee and in young healthy subjects, as reflected by changes in serum and urine biochemical markers originating from joint related collagens and proteoglycans.

Detailed Description

Not available

Study Timeline

• Study Start: 2019-01-07
• Primary Completion: 2019-05-14
• Study Completion: 2019-05-14
• Study First Submitted: 2020-08-27
• Study First Submitted QC: 2020-09-02
• Study First Posted: 2020-09-09
• Status Verified: 2021-02
• Last Update Submitted: 2021-02-12
• Last Update Posted: 2021-02-15

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
Running first	Treadmill Running followed by ergometer cycling	Treadmill running then ergometer cycling then rest
Running first	Rest	Treadmill running then ergometer cycling then rest
Cycling first	Ergometer Cycling followed by treadmill running	Ergometer cycling then treadmill running then rest
Cycling first	Rest	Ergometer cycling then treadmill running then rest

Primary Outcome Measures

Name	Time	Method
Changes in biomarkers (exploratory)	Acute: 0-4 hours and subacute: 24 hours	Serum and urine biochemical markers of collagen and proteoglycan turnover

Trial Locations

Locations (1)

Sanos Clinic; 🇩🇰 Herlev, Denmark