The Effect of Exercise on the Collagen Synthesis and Cytokine Response in Human Cartilage Tissue With Osteoarthritis
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 32
- 试验地点
- 2
- 主要终点
- Collagen synthesis in articular cartilage
研究概览
简要总结
This study will examine the effect of exercise on the turnover of collagen in articular cartilage and the content of cytokines in the synovial fluid from human adults with osteoarthritis.
详细描述
By using stabile isotope labelling, this study will track the formation and destination of newly formed cartilage collagen in adult humans scheduled for knee replacement surgery due to osteoarthritis. The collagen formation as well as the effect on the cytokine content of the synovial fluid will be examined both at rest and in response to 4 weeks of exercise/training. Overall the project aims to improve the basic understanding of cartilage development and function in relation to osteoarthritis prevention.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 40 Years 至 90 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Primary osteoarthritis of the knee scheduled for knee replacement surgery
- •Must be able to perform physical exercise
- •Age 40-90 years old
- •BMI 18.5-40 kg/m^2
- •None smoker for the last 6 weeks
排除标准
- •Regular intake of:
- •non steroid anti-inflammatory drugs (NSAID)
- •corticoid-steroids
- •disease modifying anti-rheumatic drugs (DMARD)
- •cytostatic incl. chemotherapy
- •immune suppressive medicine
- •Inflammatory diseases or cancer
- •Recent trauma to the knee (< 3 months)
- •Previous knee surgery
- •Regular strenuous exercise ( > 1 pr. month)
- •Previous exposure to tracers (e.g. from another study)
研究组 & 干预措施
Exercise group
干预措施: Exercise. (Behavioral)
Control group
结局指标
主要结局
Collagen synthesis in articular cartilage
时间窗: End of study at 4 weeks
By using incorporation of stabile isotope tracers measured by gas chromatography, the concentration of newly formed collagen will be measured.
次要结局
- Cytokine and enzymes concentration in synovial fluid(End of study at 4 weeks)
- Cytokine and enzymes concentration in blood(At the beginning and at the end of the study at 4 weeks)
- Gene expression(End of study at 4 weeks)
- Strength(At the beginning and at the end of the study at 4 weeks)
- Body mass index (BMI)(At the beginning of the study.)
- Age(At the beginning of the study.)
研究者
Adam El Mongy Jørgensen, MD
Principal Investigator, Medical Doctor
Bispebjerg Hospital