Randomized comparative clinical trial To evaluate the efficacy of Madhumehavinashini Gutika with and without Jwarahara Kashaya in the management of Madhumeha with special reference to Diabetes Mellitus Type II.

Diabetes Mellitus is a clinical syndrome characterized by hyperglycemia due to absolute or relative deficiency of insulin. It is characterized by polyuria, polydipsia, polyphagia, fatigue etc.It is one of the lifestyle disorders whose prevalence is rising more rapid in almost all countries. It is a leading cause of morbidity and mortality all over the world. Despite the availability of treatments like oral hypoglycemic agents, achieving optimal glycemic control remains challenging for many patients. The long-term effectiveness and side effects of pharmacological interventions can make  managing T2DM even more complex, thus emphasizing the need for exploring alternative therapies Though there are so many ongoing and completed studies on efficacy of Ayurvedic management of DM, most of them shows is effective in reducing the subjective parameters and no much change is observed in FBS, PPBS. So Conducting larger clinical trials with well-defined objective measures like FBS, PPBS,  and other biomarkers could help validate the effectiveness of these therapies and potentially expand treatment options for patients with T2DM. Investigating the efficacy of Jwarahara Kashaya in comparison to Madhumehavinashini gutika offers an opportunity to   potentially improve outcomes. Keeping all these facts in mind, it has been decided to conduct a clinical study entitled as “RANDOMISED COMPARATIVE CLINICAL TRIAL TO EVALUATE THE EFFICACY OF MADHUMEHAVINASHINI GUTIKA WITH AND WITHOUT JWARAHARA KASHAYA IN THE MANAGEMENT OF MADHUMEHA WITH SPECIAL REFERENCE TO DIABETES MELLITUS TYPE II”