Gastrointestinal Microcirculation During Cardiopulmonary Bypass

Completed

• Conditions: Tree Number E04.928.220; MeSH Heading Cardiac Surgical Procedures; Tree Number E04.100.376
• Interventions: Procedure: Heart Lung machine

• Registration Number: NCT01425931
• Lead Sponsor: Johann Wolfgang Goethe University Hospital

Brief Summary

O2C is a diagnostic device for non-invasive determination of oxygen supply in microcirculation of blood perfused tissues. The optical sensor is easy to handle and guarantees reproducible examinations of local oxygen supply of tissues in clinics as well as in research. The examinations are without any strain for your patient.

Determines by use of a glass fibre probe:

Blood Flow in Microcirculation Capillary-Venous Oxygen Saturation Blood Filling of Microvessels Blood Flow Velocity This device makes it possible to supervise the local oxygen supply of organs and tissue.

With it is possible to measure locally the amount of oxygen which is transported into the region of interest and to diagnose local oxygen consumption of an organ. O2C's novelty is monitoring the energetic metabolism of cells by measuring the oxygen uptake with an optical sensor probe. Pathological O2-supply, which can lead to angiogenesis or cell-death and subsequently to organ failure, now can be detected in an early state by use of the new sensor system.

One of these new developed sensors are used to place in rectal position during extracorporeal circulation to determine the microcirculation.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2011-08-23
• Study First Submitted QC: 2011-08-29
• Study First Posted: 2011-08-30
• Study Start: 2014-06
• Status Verified: 2014-08
• Primary Completion: 2014-08
• Study Completion: 2014-08
• Last Update Submitted: 2014-08-05
• Last Update Posted: 2014-08-06

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

• Patients on extracorporeal circulation

Exclusion Criteria

• Haemorrhoidal lesions

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Extracorporeal circulation	Heart Lung machine	all patients were measured by microcirculation device O2C

Primary Outcome Measures

Name	Time	Method
Blood Flow in Microcirculation	3 hours

Trial Locations

Locations (1)

Goethe University; 🇩🇪 Frankfurt am Main, Hessen, Germany