Intraoperative perfusion assessment during kidney transplantatio
- Conditions
- N18.5Chronic kidney disease, stage 5
- Registration Number
- DRKS00030097
- Lead Sponsor
- niversitätsklinikum Mannheim
- Brief Summary
The O2C tissue spectrometry device provides a quantitative method of microperfusion assessment that can be employed during kidney transplantation as an easy-to-use and highly sensitive alternative to ICG fluorescence angiography. Intraoperative microvascular flow and velocity in the allograft cortex after reperfusion predicted DGF with a sensitivity of 100% and a specificity of 82%. Threshold values of 57 A.U. for microvascular flow and 13 A.U. for microvascular velocity were identified by an ROC analysis. This study, therefore, confirmed that impairment of microperfusion of the allograft cortex directly after reperfusion was a key indicator for the occurrence of DGF after kidney transplantation. Our results support the combined use of intraoperative duplex sonography, for macrovascular quality control, and quantitative microperfusion assessment, such as O2C spectrometry, for individual risk stratification to guide subsequent postoperative management.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 26
All patients scheduled for kidney transplantation in our center.
allergy to iodine or ICG, severe hepatic dysfunction, pregnancy, hyperthyroidism, pulmonary hypertension and the logistical availability of both technical tools for quantitative perfusion assessment (O2C and SPY Elite)
Study & Design
- Study Type
- observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Delayed graft function (DGF), defined as 2 or more postoperative dialysis sessions within the hospital stay
- Secondary Outcome Measures
Name Time Method parameters of postoperative transplant function