Effects of Slow Breathing on Blood Pressure and Autonomic Function in Hypertensive Patients
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 发起方
- 入组人数
- 32
- 试验地点
- 2
- 主要终点
- blood pressure reduction
研究概览
简要总结
Hypertension is a chronic disease that affects about 23% of the brazilian population. The treatment of hypertension by pharmacological intervention is efficacious, but has side effects and significant costs. Techniques that reduce the respiratory rate are shown as a effective non-pharmacological treatment in controlling blood pressure. Evidence has shown that a slow and deep breathing rate, around 10 breaths per minute or less, significantly reduces blood pressure. However, the physiological mechanisms involved in blood pressure decrease due to decreased respiratory rate are not yet known. Therefore the goals of this study will evaluate the chronic effect of breathing exercise guided on office and 24 hours blood pressure and analyse the chronic effect of breathing exercise guided over the autonomic function in hypertensive patients in stages 1 and 2.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Hypertensive patients with or without use of antihypertensive drug therapy with office systolic blood pressure between 140 and 179 mmHg and / or office diastolic between 90 and 109mmHg).
- •Adults over 18 years.
- •Both genders.
排除标准
- •Use of medications that alter sympathetic nerve activity (beta blockers and / or sympatholytics).
- •Use of three or more classes of antihypertensive drugs
- •Secondary Hypertension
- •Chronic Respiratory Disease
- •Diabetes Mellitus.
- •Chronic Kidney Disease with Clearance Creatinine <60 ml/min
- •Congestive heart failure
- •Coronary disease
- •BMI > 30 kg/m2
结局指标
主要结局
blood pressure reduction
时间窗: 8 weeks after the randomization
The blood pressure reduction in mmHg will be verified by office blood pressure measurement and ambulatory blood pressure monitoring (ABPM)
次要结局
- autonomic regulation(8 weeks after randomization)
研究者
Decio Mion Jr.
MD, Phd
University of Sao Paulo General Hospital