NCT03161977已完成不适用
The Effect of Mannitol on Intraoperative Serum Potassium in Patients Undergoing Craniotomy：an Observational Study
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 30
- 试验地点
- 1
- 主要终点
- the concentration of serum potassium
研究概览
简要总结
This is an observational study designed to research the effect of mannitol on the concentration of intraoperative serum potassium in patients undergoing craniotomy, and to guide the safe use of mannitol during craniotomy.
详细描述
Patients were assigned to receive 20% mannitol (1g/kg) solution administered intravenously 15-20 minutes at the time of drilling skull.The serum potassium was measured by arterial blood gas analysis before infusion (T0), infusion finished (T1), 15min (T2), 30min (T3), 60min (T4) and 120min (T5) after infusion.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •age 18 to 70
- •American Society of Anesthesiologists physical status I to II
- •liver and kidney function is normal
- •preoperative concentration of serum potassium was from 3.5 to 5.5 mmol/L
排除标准
- •history or presence of congestive heart failure (New York Heart Association class III to IV)
- •history or presence of renal failure(diabetes insipidus, or syndrome of inappropriate antidiuretic hormone secretion)
- •intraoperative blood transfusion
结局指标
主要结局
the concentration of serum potassium
时间窗: two hours within infusioning mannitol
measured by arterial blood gas analysis
次要结局
未报告次要终点
研究者
研究点 (1)
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