Potential Beneficial Effects of Resveratrol on Obesity, Metabolic Syndrome and Inflammation - Emphasis on Description of the Molecular Biology Underpinning the Interplay Between Calorie Restriction, SIRT1, STAT5 and the GH/IGF-I Axis
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- University of Aarhus
- Enrollment
- 24
- Locations
- 1
- Primary Endpoint
- Metabolic parameters
Study Overview
Brief Summary
We want to investigate whether the food supplement resveratrol is able to counteract the detrimental effects of obesity.
Detailed Description
The aim of this study is to investigate potential metabolic effects of resveratrol in healthy but obese men. We hypothesize that resveratrol will counteract some of the detrimental effects of obesity, and as an imitator of calorie restriction will give new insight into the basic biochemical pathways underpinning human metabolism. Of special interest is the potential connection between resveratrol, calorie restriction, SIRT1, STAT5b and the GH/IGF-I axis.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Basic Science
- Masking
- Triple (Participant, Care Provider, Investigator)
Eligibility Criteria
- Ages
- 18 Years to — (Adult, Older Adult)
- Sex
- Male
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •BMI > 30 kg/m2
- •Otherwise healthy
- •Written informed consent
Exclusion Criteria
- •Any disease
- •Alcohol dependency
- •Allergy to trial medication
- •Present or previous malignancy
- •Participation in other clinical trials within three months before randomization
Arms & Interventions
Placebo
Intervention: Placebo (Other)
Resveratrol
Dietary supplement of resveratrol 500 mg three times a day over five weeks.
Intervention: Resveratrol (Dietary Supplement)
Outcomes
Primary Outcomes
Metabolic parameters
Time Frame: Five weeks
Regarding glucose, protein and fat metabolism.
Secondary Outcomes
- Pathways of substrate metabolism.(Five weeks)