Clinical Significance and Diagnosis of Sarcopenia in Patients With Heart Failure With Preserved Ejection Fraction
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Heart Failure With Preserved Ejection Fraction
- Sponsor
- Medical University of Lodz
- Enrollment
- 190
- Locations
- 1
- Primary Endpoint
- Arterial stiffness
- Last Updated
- 6 years ago
Overview
Brief Summary
Obesity sarcopenia, characterized by the coexistence of excess fat and muscle mass reduction, may contribute to the pathophysiology of exercise intolerance in patients with heart failure with preserved ejection fraction (HFpEF). The project will examine the impact of selected circulating miRNAs on processes that may form the pathophysiological basis for HFpEF development and obesity sarcopenia in correlation with biochemical markers, echocardiographic assessment and non-invasive assessment of hemodynamic parameters. In addition, the impact of LDL and HDL on these diseases will be assessed. Determinations of selected adipokines and asymmetric dimethylarginine will also be carried out and their effects on the cardiovascular system will be assessed.
Investigators
Agata Bielecka-Dabrowa, MD, PhD, Department of Hypertension
Principal Investigator
Medical University of Lodz
Eligibility Criteria
Inclusion Criteria
- •control group: healthy volunteers
- •study groups: patients with HFpEF. Patients in which the results of BNP/NT-proBNP did not confirm the diagnosis of HFpEF were classified as hypertensive group.
Exclusion Criteria
- •coronary artery disease
- •unstable hypertension
- •heart failure class IV NYHA
- •condition after percutaneous or surgical revascularization
- •pulmonary hypertension in echocardiography
- •obstructive or restrictive lung diseases
- •congenital heart disease
- •arrhythmias (including atrial fibrillation)
- •pacemaker or implantable cardioverter defibrillator
- •hyperthyroidism or hypothyroidism
Outcomes
Primary Outcomes
Arterial stiffness
Time Frame: through study completion, an average of 1 year
Left ventricular systolic and diastolic function
Time Frame: through study completion, an average of 1 year
The level of biochemical parameters
Time Frame: through study completion, an average of 1 year