Additional Effect of Perioperative, Compared with Preoperative, Immunonutrition After Pancreaticoduodenectomy: A Randomized, Controlled Trial
Phase 4
Completed
- Conditions
- Pancreatic head cancer, distal cholangiocarcinoma, ampullary carcinoma, IPM
- Registration Number
- JPRN-UMIN000024449
- Lead Sponsor
- Department of General Surgery, Chiba University Graduate School of Medicine
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up complete
- Sex
- All
- Target Recruitment
- 71
Inclusion Criteria
Not provided
Exclusion Criteria
age younger than 18 years ongoing infection gastrointestinal obstruction respiratory dysfunction cardiac dysfunction hepatic dysfunction renal failure history of recent immunosuppressive or immunological diseases preoperative evidence of widespread metastatic disease
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Postoperative Infectious Complication[ Time Frame: 30 days ]
- Secondary Outcome Measures
Name Time Method Plasma IL-6, PGE2, CRP, Th1/Th2 Balance. [ Time Frame: 14 days ]
Related Research Topics
Explore scientific publications, clinical data analysis, treatment approaches, and expert-compiled information related to the mechanisms and outcomes of this trial. Click any topic for comprehensive research insights.
What are the molecular mechanisms of immunonutrition in enhancing immune response post-pancreaticoduodenectomy for pancreatic head cancer?
How does perioperative immunonutrition compare to preoperative in reducing postoperative complications in patients with distal cholangiocarcinoma and ampullary carcinoma?
Which biomarkers correlate with improved outcomes in immunonutrition-treated patients with IPM and pancreatic cancer?
What adverse events are associated with perioperative immunonutrition protocols in phase IV pancreatic cancer trials?
Are there synergistic effects of combining immunonutrition with standard-of-care therapies for perioperative management of pancreaticoduodenectomy patients?