The Comparison of Local Infiltration Analgesia versus Adductor canal block on Postoperative pain and Functional outcome after Total knee replacement: A randomized clinical trial

Phase 3

Completed

• Conditions: Osteoarthritis KneeTotal knee arthroplastyPostoperative TKA analgesiaadductor canal block; Total knee arthroplasty; Postoperative analgesia; functional outcome; single shot adductor canal block; local infiltration analgesia

• Registration Number: TCTR20150720003
• Lead Sponsor: Research Affairs Faculty of medicine, Chulalongkorn University

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2015-07-20
• Study Completion: 2016-06-30
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

Patient aged > 18 years old, who was scheduled for total knee arthroplasty
American Society of anesthesiologist class 1-3
Patient BMI 18-40 kg/m2

Exclusion Criteria

refuse to participate this study
allergy to any drug in this study
age <18 years
ASA physical status > 3
BMI < 18 kg/m2, BMI > 40 kg/m2
contraindication to neuraxial anesthesia
uncontrolled hypertension or Blood pressure greater than 140/90 mmmHg
history of heart failure, cerebrovascular disease, cardiac surgery, coronary artery disease
history of upper GI bleeding, gastric ulcer
history of abnormal liver enzyme, hepatic failure, renal failure, organ transplantation, coagulopathy
chronic opioids user defined as using opioids drug almost/everyday for three consecutive months or more than 60 mg/day for one month
neuropathic pain
failure to single shot adductor canal block
inability to cooperate with Time Up and Go Test before surgery

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
morphine consumption postoperative 24 hours postoperative 24 hr mg of morphine consumption using PCA device

Secondary Outcome Measures

Name	Time	Method
degree of knee flexion(active and passive) postoperative day1,2,3 postoperative day 1, 2, 3 degree of range of motion,morphine consumption postoperative 48 hours postoperative 48 hr mg of morphine consumption using PCA device,Pain score postoperative 6,12,18 hours postoperative 6,12,18 hours visual analog scale,pain score at rest, sit, flexion, extension of the knee postoperative postoperative day 1 in the morning and evening visual analog scale,pain score at rest, sit, stand, walk postoperative postoperative day 2,3 visual analog scale,Quadriceps strength postoperative day 1, 2, 3 postoperative day 1, 2, 3 maximum voluntary isometric contraction,rehabilitation after surgery on postoperative day 3 The Timed Up and Go test (TUG),pain score postoperative 2,6,12 weeks postoperative 2,6,12 weeks visual analog scale,rehabilitation after surgery postoperative 2,6,12 weeks The Timed Up and Go test (TUG)