Efficacy of Local Infiltration Analgesia containing bupivacaine and different doses of Ketorolacin hip arthroplasty; A three-arm randomized trial

Phase 4

• Conditions: 1. Does local infiltration analgesia containing Bupivacaine plus ketorolac have more efficacy than Bupivacaine alone in post-operative THA pain control?2.Does local infiltration analgesia containi; local infiltration analgesia, hip arthroplasty, ketorolac

• Registration Number: TCTR20190627003
• Lead Sponsor: Khon Kaen University

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2019-06-27
• Study Completion: 2024-01-09
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Enrolling by invitation
• Sex: All
• Target Recruitment: 96

Inclusion Criteria

Adult aged 20-75 years indicated for unilateral total hip arthroplasty
ASA class I or II

Exclusion Criteria

oSevere hip deformities or required extensive soft tissue release:
-Hip deformities > 30oin any planes
-Limb shortening correction > 3 centimeters
oContraindicated to spinal anesthesia or failed to complete spinal anesthesia
oRenal function impairment; GFR <50 mL/min
oHigh risk for cardiovascular thrombotic event; eg, history of myocardial infarction, thrombotic stroke
oHistory of peptic ulcer or gastrointestinal(GI) bleeding
oHistory of long-term (>1 month) use of daily opioid medication with an oral morphine equivalent (OME) of >5 mg/day
oHistory of short-term (<1 month) use of daily opioid medication (average OME of >30 mg/day)
oHistory of allergy of bupivacaine, ketorolac, morphine
oUnable to provide consent, pain information and cognitive impairment
oIntraoperative fractures of both femur and acetabulum

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Opioid consumption 5 timepoints postoperation milligrams of opioid

Secondary Outcome Measures

Name	Time	Method
Pain 5 timepoints postoperation Visual analoque scale