Ketanest in septic shock.
Recruiting
- Conditions
- Patients in need for intubation in early septic shock.
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 20
Inclusion Criteria
1. Septic shock (see below);
2. In need for ventilatory support;
Exclusion Criteria
1. <18 and >80 years old;
2. Symptomatic coronary artery disease;
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method These variables are measured every hour during the first 8 hours. However, these variables will be measured every 10 minutes during:<br /><br>1. The two hour following the induction of anesthesia (0-2h);<br /> <br>2. The two hour after the switch to midazolam/fentanyl anesthesia (2-4).<br><br /><br /><br>1. CVP (10 min average);<br /><br>2. HR/BP (10 min average);<br /><br>3. MAP (10 min average);<br /><br>4. Urine output (60 min average);<br /><br>5. ScvO2 and arterial blood analysis (every 30 minutes);<br /><br>6. Resuscitation volume (specific sum);<br /><br>7. Inotropic support (value of rate and cumulative dose);<br /><br>8. Vasopressor support (value of rate and cumulative dose).<br>
- Secondary Outcome Measures
Name Time Method 1. Ventilatory and oxygen delivery variables:<br>Airway pressures / FiO2 / tidal volume / Lactate /Hb, are measured every hour during the first 4 hours, and after 8 hours;<br /><br><br>2. Adverse psychological reactions:<br>During the observation period, checking the medical record upto 24 hours after induction, and, if possible, asking the patient for adverse psychological effects as soon as possible after awaking and after extubation;<br /><br><br>3. Adrenal gland responsiveness:<br>Before induction: basal serum total cortisol, free cortisol, and 11beta-deoxycortisol<br>At 6 and 24 hrs after induction of anesthesia: basal serum total cortisol, free cortisol, and 11beta-deoxycortisol followed by a standard high dose (250 ug of synthetic ACTH) Synacthentest, with measurements of total, free cortisol and 11-beta deoxycortisol at 0, 30 and 60 minutes;<br /> <br><br>4. Inflammatory markers: <br>Baseline, 6 and 24 hours: IL6, TNFa. <br>