Antecolic Versus Retrocolic Gastrojejunostomy During Whipple's Procedure

Not Applicable

Recruiting

• Conditions: Pancreatic Cancer Resectable; Pancreas Neoplasms

• Registration Number: NCT06914349
• Lead Sponsor: University of Thessaly

Brief Summary

Aim: This randomized clinical study aims to compare occurrence of DGE in patients undergoing either antecolic or retrocolic gastrojejunostomy following pancreaticoduodenectomy.

Methods: Participants of this study will be patients undergoing pylorus preserving pancreaticoduodenectomy at the Surgical Department of the University Hospital of Larissa. Patients will be randomized to undergo either an antecolic or a retrocolic gastrojejunostomy and the occurrence of DGE will then be compared between the two groups. Individuals younger than 18 or older than 75 years old, as well as patients who do not consent to participate in this trial, will be excluded.

Expected results: Based on available literature, antecolic gastrojejunostomy may be related with a lower incidence of DGE, without a statistically significant difference between the two methods. We aim to show if one of the two methods of gastrointestinal reconstruction (antecolic versus retrocolic) affects DGE.

Detailed Description

Not available

Study Timeline

• Status Verified: 2025-03
• Study Start: 2025-03-30
• Study First Submitted: 2025-03-30
• Study First Submitted QC: 2025-03-30
• Study First Posted: 2025-04-06
• Last Update Submitted: 2025-06-05
• Last Update Posted: 2025-06-06
• Primary Completion: 2028-03-31
• Study Completion: 2029-03-31

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 76

Inclusion Criteria

• Age over 18 years old
• Elective pancreaticoduodenectomy
• Signed consent form

Exclusion Criteria

• Age under 18 years old
• Patients who are participants in other trials that may affect the results of this study
• Patients who do not consent to participate in the study

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Primary Outcome Measures

Name	Time	Method
Delayed Gastric Emptying	3 years	The occurence of delayed gastric emptying will be compared between two groups of patients: those who undergo an antecolic gastrojejunostomy and those who undergo a retrocolic approach.

Trial Locations

Locations (1)

University of Thessaly; 🇬🇷 Larissa, Greece