Non Genetic Factors in the Pathogenesis of Inflammatory Bowel Disease in Twins
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 200
- 试验地点
- 1
- 主要终点
- Difference in T cell phenotypes and antigen presenting cells between twin pairs discordant for IBD
研究概览
简要总结
This study aims to investigate the role of non-genetic factors in the pathogenesis of inflammatory bowel disease.An exploratory study to investigate differences between the epigenome, microbiota and functional immunology in twins discordant for inflammatory bowel disease.
详细描述
Background: The inflammatory bowel diseases (IBD), Crohn's Disease (CD) and Ulcerative Colitis (UC), are debilitating conditions with a complex aetiology. The biggest risk factor for developing IBD is having an affected first degree relative. However when an identical twin is diagnosed with IBD, the other twin goes on to develop the condition in only 20-55% of cases.
Recent research suggests the microbiota the ecosystem of bacteria within the gut may trigger disease in susceptible individuals. Another important research area is the epigenome changes to the structure and regulation of our genome which occur throughout our life. It is known that siblings of Crohn's Disease sufferers have a changes to the immune system characteristic of Crohn';s. However it is not known whether these changes are due to genetic similarity or shared environment. Comparison between mono and dizygotic twins elucidates the relative importance of genetic and environmental factors.
Primary Objective: An exploratory study to investigate differences between the epigenome, microbiota and functional immunology in twins discordant for inflammatory bowel disease.
Study Design: Multicentre basic science study involving human participants
Planned sample size: 200 data subjects (100 twin pairs)
研究设计
- 研究类型
- Observational
- 观察模型
- Family Based
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Monozygotic twins discordant for IBD
- •Monozygotic twins concordant for IBD
- •Dizygotic twins discordant for IBD
- •Dizygotic twins concordant for IBD
- •Healthy controls
排除标准
- •<18 years old
- •Antibiotics within past 3 months of sample collection
- •Unable to give informed consent
结局指标
主要结局
Difference in T cell phenotypes and antigen presenting cells between twin pairs discordant for IBD
时间窗: 1 day (1 visit only)
Difference in microbiota composition and metabolomic profiles between IBD phenotypes
时间窗: 1 day (1 visit only)
Difference in DNA methylation patterns between twin pairs
时间窗: 1 day (1 visit only)
Comparison of microbiota composition and metabolic profiles with DNA methylation patterns
时间窗: 1 day (1 visit only)
次要结局
未报告次要终点