Genetic Risk factors for Multi-system Inflammatory Syndrome in Children and Pediatric Post COVID condition (GRIP) - GRIP

eids Universitair Medisch Centrum0 个研究点目标入组 400 人开始时间: 待定最近更新: 2024年4月9日

试验速览

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•1. Children with a history of MIS-C: as defined according to WHO criteria [36],
•who were 0-18 at the time of MIS-C
•2. Children with post-COVID condition who were 0-18 at the time of SARS-CoV-2
•infection: as defined according to the WHO case definition [37].
•This includes a history of probable or confirmed prior SARS-CoV-2 infection,
•with signs and symptoms (including fatigue, shortness of breath, cognitive
•dysfunction) that are present after 12 weeks, last at least 2 months, have an
•impact on daily functioning and are not explained by an alternative diagnosis.
•Post-COVID condition must be diagnosed by a pediatrician.
•3. *Exposed* control group: children with a history of proven SARS-CoV-2
•infection (RT-PCR, antigen test or serology positive) who were 0-18 at the time
•of SARS-CoV-2 infection.

•1. Group 1 (MIS-C): no specific exclusion criteria
•2. Group 2 (post-COVID condition): other plausible cause of symptoms AND/OR a
•history compatible with chronic fatigue syndrome prior to infection with
•SARS-CoV-2. Children with a history of MIS-C who suffer prolonged signs and
•symptoms will be included in the MIS-C group. Patients who were not diagnosed
•with Post-COVID condition by a pediatrician, but only by for example a general
•practitioner, are excluded.
•3. Group 3 (*exposed* control group): MIS-C or post-COVID condition; AND/OR
•Moderate or severe course of COVID-19, defined as: need for supplemental oxygen
•and/or intensive care admission because of COVID-19 and/or death. Children are
•also excluded when they have had a vaccination against SARS-CoV-2, before their
•first infection with this virus. Also, the children in de the exposed control
•group are excluded when their parents/siblings (1st degree family) suffer(-ed)
•from MIS-C or post-COVID condition.

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