The Effect of Leukocyte and Platelet-rich Fibrin With Antimicrobial Photodynamic Therapy in Treatment of Aggressive Periodontitis Patients: A Randomized Controlled Clinical Trial
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 20
- 试验地点
- 2
- 主要终点
- Radiographic evaluation and measurements of the defect in millimeters
研究概览
简要总结
Antimicrobial photodynamic therapy (aPDT) is associated with photosensitizing agents which promote the generation of free radicals and singlet oxygen, which are cytotoxic to certain bacteria. Leukocyte and platelet-rich fibrin (L-PRF) has been used extensively in the treatment of intrabony defects and achieved excellent results. It acts as an immune regulation node with inflammation control abilities, including a slow continuous release of growth factors which stimulates periodontal regeneration. The aim of this study is to evaluate the adjunctive effects of aPDT with and without L-PRF in aggressive periodontitis patients.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double (Participant, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 40 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •systemically healthy
- •non- smoker,
- •not received any periodontal treatment within the last 6 months,
- •no antibiotics, anti- inflammatory drugs or any other medication taken within the last 6 months
排除标准
- •any systemic disease that might influence the prognosis of periodontal disease and outcome of the treatment,
- •any medical condition that required antibiotic prophylaxis before the treatment,
- •pregnancy and lactation,
- •ingestion of antibiotics, anti-inflammatory drugs or any other medication during the study period,
- •any physical limitations or restrictions that might preclude normal oral hygiene procedures.
结局指标
主要结局
Radiographic evaluation and measurements of the defect in millimeters
时间窗: 9 months
Changes in bone formation in millimeters after application of antimicrobial photodynamic therapy with and without L-PRF
Clinical evaluation and measurements of the defect in millimeters
时间窗: 9 months
Changes in clinical measurements in millimeters after application of antimicrobial photodynamic therapy with and without L-PRF
次要结局
未报告次要终点
研究者
Dalia Rasheed Issa
principle investigator
Kafrelsheikh University