The Effect of Leukocyte and Platelet-rich Fibrin With Antimicrobial Photodynamic Therapy in Aggressive Periodontitis

Not Applicable

Recruiting

• Conditions: L-PRF; Photodynamic Therapy; Aggressive Periodontitis
• Interventions: Procedure: L-PRF with antimicrobial photodynamic therapy; Procedure: antimicrobial photodynamic therapy without L-PRF

• Registration Number: NCT05043935
• Lead Sponsor: Kafrelsheikh University

Brief Summary

Antimicrobial photodynamic therapy (aPDT) is associated with photosensitizing agents which promote the generation of free radicals and singlet oxygen, which are cytotoxic to certain bacteria. Leukocyte and platelet-rich fibrin (L-PRF) has been used extensively in the treatment of intrabony defects and achieved excellent results. It acts as an immune regulation node with inflammation control abilities, including a slow continuous release of growth factors which stimulates periodontal regeneration. The aim of this study is to evaluate the adjunctive effects of aPDT with and without L-PRF in aggressive periodontitis patients.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2021-08-20
• Study First Submitted QC: 2021-09-05
• Study First Posted: 2021-09-14
• Study Start: 2021-11-22
• Status Verified: 2024-04
• Last Update Submitted: 2024-04-09
• Last Update Posted: 2024-04-11
• Primary Completion: 2024-09
• Study Completion: 2024-10

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

• systemically healthy
• non- smoker,
• not received any periodontal treatment within the last 6 months,
• no antibiotics, anti- inflammatory drugs or any other medication taken within the last 6 months

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Exclusion Criteria

• any systemic disease that might influence the prognosis of periodontal disease and outcome of the treatment,
• any medical condition that required antibiotic prophylaxis before the treatment,
• smoking,
• pregnancy and lactation,
• ingestion of antibiotics, anti-inflammatory drugs or any other medication during the study period,
• any physical limitations or restrictions that might preclude normal oral hygiene procedures.

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
L-PRF with antimicrobial photodynamic therapy	L-PRF with antimicrobial photodynamic therapy	Application of L-PRF with antimicrobial photodynamic therapy in the defect
antimicrobial photodynamic therapy	antimicrobial photodynamic therapy without L-PRF	Application antimicrobial photodynamic therapy in the defect

Primary Outcome Measures

Name	Time	Method
Radiographic evaluation and measurements of the defect in millimeters	9 months	Changes in bone formation in millimeters after application of antimicrobial photodynamic therapy with and without L-PRF
Clinical evaluation and measurements of the defect in millimeters	9 months	Changes in clinical measurements in millimeters after application of antimicrobial photodynamic therapy with and without L-PRF

Trial Locations

Locations (1)

Faculty of Dentistry, Kafrelsheikh University; 🇪🇬 Kafr Ash Shaykh, Egypt