Impact of Genetic Polymorphisms on Dental Implant Loss

Not Applicable

Completed

• Conditions: Patients Treated by Means of 1 or More Dental Implants
• Interventions: Other: anamnesis; Procedure: oral examination; Procedure: Blood sample

• Registration Number: NCT01274442
• Lead Sponsor: University Hospital, Ghent

Brief Summary

Patients that may participate in this case-control study underwent dental implant surgery in the University Hospital in Ghent in 2004-2007.

According to one of our recent papers based on this patient group, 34/461 patients lost one or more implants. The goal is to invite these 34 patients, to update the anamnesis, to perform a brief clinical oral examination and to have a blood sample. The latter is necessary to identify relevant genetic polymorphisms of the patient that are associated with implant loss. Among the remaining patients that did not lose implants, another 34 'controls' will be invited for the same examinations.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2011-01-10
• Study First Submitted QC: 2011-01-10
• Study First Posted: 2011-01-11
• Study Start: 2011-06-01
• Primary Completion: 2013-08-05
• Study Completion: 2013-08-05
• Status Verified: 2022-12
• Last Update Submitted: 2022-12-28
• Last Update Posted: 2022-12-29

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 13

Inclusion Criteria

• Dental implant surgery in the University Hospital in Ghent in 2004-2007.
• Case: dental implant loss
• Control: no dental implant loss

Exclusion Criteria

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
CASE: patients lost one or more implants	Blood sample	Group of patients who received an implant during a dental implant surgery in the University Hospital in Ghent in 2004-2007, but who lost one or more implants.
CONTROL: no dental implants lost	oral examination	Group of patients who received an implant during a dental implant surgery in the University Hospital in Ghent in 2004-2007, who did not lose their implants.
CASE: patients lost one or more implants	oral examination	Group of patients who received an implant during a dental implant surgery in the University Hospital in Ghent in 2004-2007, but who lost one or more implants.
CONTROL: no dental implants lost	anamnesis	Group of patients who received an implant during a dental implant surgery in the University Hospital in Ghent in 2004-2007, who did not lose their implants.
CONTROL: no dental implants lost	Blood sample	Group of patients who received an implant during a dental implant surgery in the University Hospital in Ghent in 2004-2007, who did not lose their implants.
CASE: patients lost one or more implants	anamnesis	Group of patients who received an implant during a dental implant surgery in the University Hospital in Ghent in 2004-2007, but who lost one or more implants.

Primary Outcome Measures

Name	Time	Method
genetic polymorphisms associated with implant loss	after 3 to 6 years	Identification of genetic polymorphisms that are associated with implant loss. It concerns only one evaluation (1 blood sample).

Trial Locations

Locations (1)

University Hospital Ghent; 🇧🇪 Ghent, Belgium