Based on the theory of 'liver and kidney homology' to explore the clinical application of TCM prevention and treatment in PATIENTS with HR-positive breast cancer
- Conditions
- Breast Cancer
- Registration Number
- ITMCTR2200005735
- Lead Sponsor
- onghua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Female
- Target Recruitment
- Not specified
1. Aged between 18 and 65;
2. Patients diagnosed as breast cancer by pathology and HR positive by immunohistochemistry;
3. Completed surgery, chemotherapy, radiotherapy, and/or targeted therapy;
4. Have received AIs (anastrozole, Letrozole, exemestane) for at least 2 months;
5. TCM syndrome differentiation belongs to liver and kidney deficiency (symptoms include tenderness of waist and knee, stiffness of joints, dizziness, etc.);
6.KPS score =60;
7. The expected survival is more than 6 months;
8. Signed the informed consent and voluntarily accepted the treatment plan of the study.
1. Bone mineral diseases: such as hypoparathyroidism or hyperthyroidism, malformed osteitis, osteogenesis imperfection, osteomalacia, etc.;
2. Diseases that affect bone metabolism, such as Cushing's syndrome, hyperthyroidism, rheumatism or rheumatoid arthritis;
3. Steroid hormones or anticonvulsants were used for more than 6 months before the study;
4. Used hormone replacement therapy within 6 months, such as glucocorticoid, parathyroid hormone, estrogen, etc.;
5. Had surgery related to extremities within 6 months;
6. Complicated with serious primary diseases of cardiovascular, liver, kidney and hematopoietic systems;
7. Patients with obvious disease progression and distant metastasis during the study;
8. Psychopaths with cognitive impairment or mental abnormalities.
Study & Design
- Study Type
- Interventional study
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method WOMAC;
- Secondary Outcome Measures
Name Time Method Bone density test;TCM symptom and sign scoring;Growth hormone(GH);Bone metabolism indicators (25-Hydroxy-vitamin-D, ß-CTX, osteocalcin);