Based on the ''spleen-stomach-intestine-kidney'' axis, the evidence-based evaluation of the clinical efficacy of Qihuangyi kidney granules in the prevention and treatment of diabetic kidney disease and the study of biological mechanisms were discussed
- Conditions
- Diabetic kidney disease
- Registration Number
- ITMCTR2022000035
- Lead Sponsor
- Wangjing Hospital, China Academy of Chinese Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- All
- Target Recruitment
- Not specified
(1) Meet the diagnostic criteria for diabetic kidney disease;
(2) Age 30 to 85 years old;
(3) Blood pressure = 150/90mmHg;
(4) Glycosylated hemoglobin = 8.5%;
(5) eGFR=25ml/min
(6) Sign the informed consent form and follow up on time.
(1) Blood pressure < 90/60mmHg;
(2) Blood creatinine doubled in the past six months;
(3) Unilateral or bilateral renal artery stenosis;
(4) Serious large vascular events have occurred in the past six months;
(5) Complicated by malignant tumors, hematologic diseases and other serious diseases;
(6) There is a serious psychological or mental abnormality;
(7) Pregnant or lactating women;
(8) Considering other renal diseases complicated by other kidney diseases (such as urinary tract infections, urinary sediment activity manifestations (red blood cells), etc.) that require renal puncture to confirm the diagnosis;
(9) Those who have undergone dialysis or kidney transplantation.
Note: Any of the above conditions will not be included.
Study & Design
- Study Type
- Interventional study
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 24-hour urine protein quantification;
- Secondary Outcome Measures
Name Time Method urea nitrogen;Estimated glomerular filtration rate;Urine microalbumin to creatinine ratio;Serum creatinine;TCM symptom score;metabolomics;Gut flora;