Clomiphene citrate vs letrozole in patients undergoing intra uterine semen injectio
Phase 2
- Conditions
- Infertility.Female infertility
- Registration Number
- IRCT138712141744N1
- Lead Sponsor
- Vice chancellor for research, Lorestan University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- Female
- Target Recruitment
- 160
Inclusion Criteria
patients candidate of IUI( ovulatory factor; male factor infertility; patients with cervical factor; endometriosis and idiopathic infertility); Normal Pelvic USG and bilateral tubal patency.
Exclusion Criteria
Age more than 35; FSH more than 10 on day 3 of menstruation cycle; Uterine and adnexal pathology e.g. leiomyoma; Ovarian cyst on USG., Impaired hepatic /renal function; Diabetes mellitus; History of hypersensitivity to the study drug or to its excipients; Bilateral tubal obstruction on HSG
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Pregnancy rate. Timepoint: 14 days after intra uterine insemination. Method of measurement: Blood test for assay of BHCG.;Abortion rate. Timepoint: From positive test of BHCG to 20th weeks of gestation. Method of measurement: Pregnancy loss before 20th weeks of gestation determined with ultrasunogeraphy.
- Secondary Outcome Measures
Name Time Method Endometrial thickness. Timepoint: In the time of HCG injection. Method of measurement: Transvaginal ultrasonogeraphy.;Number of follicles. Timepoint: In the time of HCG injection. Method of measurement: Transvaginal ultrasonograghy.;Serum estradiol level. Timepoint: In the time of hCG injection. Method of measurement: Blood test(microgram/dl).