Value of Heart Rate Lowering Therapy in Acute Myocarditis
- Registration Number
- NCT06312891
- Lead Sponsor
- Assiut University
- Brief Summary
To study the value of heart rate lowering therapy "pharmacological rest" on the short term in cases of myocarditis without LV dysfunction.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 150
Inclusion Criteria
-
Adults: ≥18 years of age.
-
Presentation: at least one of the following:
- Myopericarditis/ACS-like
- MINOCA
- Arrhythmias: brady or tachyarrhythmias.
- Unexplained compensated acute cardiomyopathy (excluded ischemic, valvular, hypertensive, metabolic, and toxic causes of cardiomyopathy as indicated clinically).
-
TTE: LVEF>40%
-
CMR-confirmed myo(peri)carditis (Lake Louise criteria)
Exclusion Criteria
-
• Rheumatic carditis.
- Connective tissue diseases (-ve ANA).
- Cancer chemotherapy.
- Toxicity from immunotherapy.
- Vaccine-related myocarditis.
- Presence of coronary artery disease.
- Peripartum (occurring during the last month of pregnancy or within 5 months after delivery)
- ECG: atrial fibrillation/flutter.
- Resuscitated sudden death.
- Early/initial phase of decompensated heart failure.
- Tamponade complicating pericarditis unless successfully managed.
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description Conventional ttt PLUS Ivabradine. Ivabradine -
- Primary Outcome Measures
Name Time Method Value of Heart Rate Lowering Therapy in Acute Myocarditis baseline To study the value of heart rate lowering therapy "pharmacological rest" on the short term in cases of myocarditis without LV dysfunction.
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Heart Hospital
🇪🇬Assiut, Egypt