Individual Differences in Gait and Osteoarthritis Pain
概览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 300
- 试验地点
- 1
- 主要终点
- 6 minute walk test pain intensity
概览
简要总结
The goal of this observational study is to look at inter-individual differences in knee osteoarthritis (OA) walking pain and performance. The main questions this study aims to answer are:
Why do some people with knee osteoarthritis have more severe disabling pain than others, even though the degenerative changes in their knees are similar?
What are the factors that contribute to walking pain in people with knee osteoarthritis?
Participants will complete surveys, perform physical function tasks, get a knee X-ray and MRI, undergo non-invasive brain imaging, and undergo sensory testing.
详细描述
This observational study will identify biopsychosocial factors that contribute to inter-individual differences in walking pain and pain limiting walking with the hypothesis that neural processes play a key role. This study's objective is to elucidate "whole person" biopsychosocial mechanisms of movement-evoked pain and pain limitations on function in knee OA, helping to determine why some patients have severe disabling pain while others do not despite similar degenerative changes of the knee joint. Three hundred participants with knee OA will undergo a comprehensive data collection over two study visits, including surveys, exercise tasks, non-invasive brain and joint imaging, and biomechanics assessments during mobility. Using advanced analysis, this dataset will be used to identify factors contributing to walking-evoked pain and functional limitations in knee osteoarthritis.These results will identify new therapeutic targets to maintain or improve physical activity in patients with knee osteoarthritis, leading to better outcomes of physical therapy and improved overall health and well-being.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 45 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Knee pain for greater than 6 months.
- •Moderate-to-severe knee pain (\>3/10) due to osteoarthritis, as defined by American College of Rheumatology and EULAR diagnostic criteria, on \>50% of days in the past month.
- •KL grade 2-4 indicating significant degenerative changes on knee X-ray.
- •45-80 years old
排除标准
- •Inflammatory arthritis (e.g. rheumatoid arthritis).
- •More intense pain due to another chronic pain syndrome (e.g. fibromyalgia, hip osteoarthritis)
- •Significant pain or weakness in the lower extremities due to a neurological condition (e.g. lumbar radiculopathy, paresis due to stroke)
- •Acute pain that is more intense than knee osteoarthritis pain
- •Current routine use of more than 15 mg oral morphine equivalents per day (use of \<15 mg OME does not exclude the participant).
- •Recent new medication, exercise, behavioral, or complementary and integrative treatment started in the last month. Stable use of these treatments for greater than 1 month does not exclude the participant.
- •Recent intra-articular injection of steroid or other agent (greater than 1 month does not exclude the participant)
- •Recent knee radiofrequency ablation (greater than 3 months does not exclude the participant)
- •Recent knee arthroscopic surgery (greater than 3 months does not exclude the participant)
- •History of knee replacement or open knee surgery on the index knee, defined as the more painful knee on average over the last month.
研究组 & 干预措施
Chronic knee pain with knee osteoarthritis
Adults 45-80 years old who have moderately severe knee osteoarthritis. They must have experienced knee pain for greater than 6 months and rate their daily knee pain at >3 on a 0-10 numeric rating scale.
结局指标
主要结局
6 minute walk test pain intensity
时间窗: 6 minutes
Pain intensity on numeric rating scale (0-10) during and around the time of the 6-minute walk test.
次要结局
- Distance walked in the 6-minute walking test(6 minutes)
研究者
Benedict Alter
Assistant Professor
University of Pittsburgh