Comparison Between Erythromycin and Neomycin Treatment of Hepatic Encephalopathy

Not Applicable

• Conditions: Hepatic Encephalopathy; Hypertension, Portal; Liver Cirrhosis
• Interventions: Drug: Erythromycin; Drug: Neomycin

• Registration Number: NCT01097811
• Lead Sponsor: UPECLIN HC FM Botucatu Unesp

Brief Summary

Comparison between the efficacy of two different antibiotics in patients with overt hepatic encephalopathy. The study is randomized, controlled and double-blinded.

Detailed Description

Not available

Study Timeline

• Study Start: 2008-06
• Study First Submitted: 2010-03-31
• Study First Submitted QC: 2010-03-31
• Status Verified: 2010-04
• Study First Posted: 2010-04-02
• Last Update Submitted: 2010-04-27
• Last Update Posted: 2010-04-28
• Primary Completion: 2010-06
• Study Completion: 2010-12

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

• Hepatic cirrhosis or portal hypertension
• Hepatic Encephalopathy

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Exclusion Criteria

• Acute liver failure
• Neuropsychiatric diseases
• Inflammatory bowel diseases
• Intestinal obstruction
• Shock
• Renal insufficiency
• Alcoholic hepatitis
• Alcohol abuse
• Antibiotic premedication

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: FACTORIAL

Arm && Interventions

Group	Intervention	Description
Erythromycin	Erythromycin	-
Neomycin	Neomycin	-

Primary Outcome Measures

Name	Time	Method
Recovery of hepatic encephalopathy	three years	comparison of efficacy between two drugs for the treatment of hepatic encephalopathy

Secondary Outcome Measures

Name	Time	Method
length of hospitalization caused by hepatic encephalopathy	three years	comparison of efficacy between two drugs for reducing the length of hospitalization during treatment of hepatic encephalopathy

Trial Locations

Locations (1)

Faculdade de Medicina de Botucatu - Universidade Estadual Paulista; 🇧🇷 Botucatu, São Paulo, Brazil