Azithromycin vs. clarithromycin for the treatment of chronic sinusitis
- Conditions
- Chronic sinusitis.Chronic sinusitis
- Registration Number
- IRCT20201209049661N1
- Lead Sponsor
- Technology and Research Vice-chancellery, Hormozgan University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 58
Diagnosis of chronic sinusitis based on the Rhinosinusitis Task Force (RTF) criteria
Confirmation of chronic sinusitis by CT scan
18-65 years of age
Presence of polyp, mass, or severe nasal septal deviation (requiring surgery or obstructing the sinus ostia) upon endoscopic examination
Antibiotic use within the past 3 months
Any topical drug (drop or spray) within the past month
Sinus or nasal surgery
Hypersensitivity to macrolides
Pregnancy or lactation
Diabetes mellitus
Hypertension
Cardiovascular diseases
Periodontal infection of the tooth roots adjacent to the maxillary sinus
Systemic illnesses involving the sinuses including Wegener's granulomatosis, sarcoidosis, malignancies, lymphoma, cystic fibrosis, AIDS, primary ciliary dyskinesia
CT scan findings of inhomogeneous densities indicating probable fungal infections, unilateral involvement of the maxillary sinuses, and presence of mucous retention cysts in the maxillary sinus
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Improvement of imaging findings. Timepoint: At the end of 4 weeks of treatment. Method of measurement: LMS (Lund-Mackay Staging) score.;Improvement of sinusitis symptoms. Timepoint: At the end of 4 weeks of treatment. Method of measurement: Patient's history.
- Secondary Outcome Measures
Name Time Method