Effects of testosterone on urea metabolism in men with hypogonadism
- Conditions
- HypogonadismMetabolic and Endocrine - Other endocrine disordersMetabolic and Endocrine - Other metabolic disorders
- Registration Number
- ACTRN12616000577415
- Lead Sponsor
- Western Sydney Local Health District
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Male
- Target Recruitment
- 8
1.Diagnosed hypogonadism;
2.Adequate replacement of other hormones in case of hypopituitarism;
3.Able to comprehend the requirements and procedures for the study and to provide informed consent before entering the study
1.Any acute condition or exacerbation of chronic conditions that in the investigators opinion would interfere with the trial visit schedule and procedures;
2.Cancer, diabetes mellitus, immunosuppressive steroid therapy and chronic renal or hepatic illnesses;
3.People in existing dependent or unequal relationships with any member of the research team;
4.People who may be involved in illegal activity;
5.People highly dependent on medical care;
6.Patients who had received an investigational new drug within the last 6 month;
7.Patients with a cognitive impairment, an intellectual disability or a mental condition which interfere with the patient's ability to understand the requirements of the study;
8.Inability to give written informed consent.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method rea metabolism, assessed by plasma urea turnover studies using stable isotopes[At baseline and 2 weeks post commencement of testosterone treatment.]
- Secondary Outcome Measures
Name Time Method Protein metabolism by plasma leucine turnover studies using stable isotopes[At baseline and 2 weeks post commencement of testosterone treatment.]