Predictors of Severe Exacerbation in Chronic Obstructive Pulmonary Disease Patients
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 102
- 试验地点
- 1
- 主要终点
- Respiratory Muscle Strength
研究概览
简要总结
Objective: To investigate the predictive ability of respiratory muscle strength, functional capacity, pulmonary function, and arterial blood gas analysis for severe exacerbation in patients with COPD.
Study Design: The study will employ a retrospective, cross-sectional study design.
Sample: Retrospective data will be taken from Metro Hospitals and Heart Institute, Noida, India.
Sample size: The total sample size for the present trial will be 102.
Independent Variable:
Respiratory Muscle Strength
Functional Capacity
Pulmonary Lung Tests
Arterial Blood Gas Analysis
Dependent Variable: Severe acute exacerbation of COPD (AECOPD)
Covariates Adjustment will be done.
Statistical Analysis: Regression analysis.
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 40.00 Year(s) 至 80.00 Year(s)（—）
- 性别
- All
入选标准
- •Age is 40 years to 80 years.
- •Sex is Males and Females.
- •Participants had a clinical diagnosis of COPD confirmed by spirometry value FEV1/FVC less than 0.70 and a grade II, III, or IV airflow limitation according to the Global Initiative for Chronic Obstructive Lung Disease (GOLD) criteria.
- •The grades of the COPD classified as moderate GOLD Stage II where FEV1 greater than or equal to 50% predicted but less than 80% predicted, severe GOLD Stage III where FEV1 is greater than or equal to 30% predicted but less than 50% predicted, very severe GOLD Stage IV where FEV1 is less than 30% predicted.
- •Patients who are hospitalised for severe exacerbation of COPD experience worsening symptoms for a duration of less than 2 weeks.
排除标准
- •Patients with additional active inflammatory diseases such as Rheumatoid Arthritis, Systemic Lupus Erythematous, Fibromyalgia, and Inflammatory Bowel Syndrome.
- •The patient presented with Myopathy.
- •Patients with other obstructive pulmonary diseases such as Asthma, Asthma-COPD Overlap Syndrome (ACOS).
- •Patient who had Unstable Angina and Acute Myocardial Infraction.
结局指标
主要结局
Respiratory Muscle Strength
时间窗: At Baseline
次要结局
- Six-Minute Walk Tests (6-MWT)
研究者
Mahima mayee Tripathy
Jamia Millia Islamia