The Effect of 2 Weeks of Supplementation of a High-gelling, High-viscous Dietary Fibre on Energy Intake
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 35
- 试验地点
- 2
- 主要终点
- Energy intake
研究概览
简要总结
Dietary fibre seems to have a relevant role in body weight management. In an acute study the investigators found that high viscous-high gelling pectin increased feelings of satiety. The objective of this study is to study the effects of 2 weeks of supplementation of high gelling-high viscous fibre or a high gelling-high viscous non-fibre control on energy intake.
The investigators do this by measuring the difference in ad libitum energy intake after 15 days of pectin or 15 days of control supplements. The investigators will further measure differences in 24h feelings of satiety, fasting blood glucose and insulin, fermentation and composition of microbiota.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 30 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Age: 18-30 year
- •BMI: 18.5-25 kg/m2
- •Healthy: as judged by the participant
- •H2 producer
排除标准
- •Weight loss or weight gain of more than 5 kg during the last 2 months
- •Using an energy restricted diet during the last 2 months
- •Lack of appetite for any reason
- •Restrained eater
- •Heavy alcohol use: >5 drinks/day
- •Reported stomach or bowel diseases or disorders (e.g. irritable bowel syndrome)
- •Reported diabetes
- •Reported thyroid disease or any other endocrine disorder
- •Using medication other than birth control, paracetamol, aspirin, hey fever and asthma
- •Antibiotic use <2 months before the study
- •Reported intolerance, allergy, or not liking of the research foods
- •Vegetarian
- •Current dietary fibre supplementation
- •Fasting glucose levels >5.8 mmol/l
- •Experienced any problems with drawing blood in the past
- •Thesis students or employees of the division of Human Nutrition
- •Volunteers who participated in the ProVe study
结局指标
主要结局
Energy intake
时间窗: change from placebo after 2 weeks
after 14 days of both intervention and placebo supplements ad libitum energy intake is measured for 3 days in a row. The change in energy intake will be calculated.
次要结局
- satiety(change from placebo after 1 day and 15 days)
- fasting glucose(change from placebo after day 0, 1 and 15)
- fasting insulin(change from placebo after day 0, 1 and 15)
- fasting leptin(change from placebo after day 0, 1 and 15)
- hydrogen in breath(change from placebo after day 2 and 15)
- energy intake(change from placebo after day 0 and 1)
- body weight(change from placebo after day 0,1,2,14,15, 16 and 17)
- adverse events(daily from day 0 to day 16)