NCT00958399已完成不适用
Satiety, Glycemic, and Gastrointestinal Effects of Novel Fibers
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 20
- 试验地点
- 2
- 主要终点
- Satiety
研究概览
简要总结
Research suggests dietary fiber may play a role in weight management, and fiber consumption is inversely associated with body weight, body fat, and BMI in cross-sectional studies. These effects may be mediated by increased satiety, reduced food intake, or changes in blood levels of glucose, insulin, and gut hormones.
The purpose of this study is to determine the satiety, glycemic, hormonal, and gastrointestinal responses of novel fiber supplements.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •healthy men and women
- •age 18-60 years
- •non-smoking
- •not taking medication
- •non-dieting (weight stable in prior 3 months)
- •BMI 18-27
- •English literacy
- •ability to give blood
排除标准
- •do not regularly consume breakfast
- •food allergies to ingredients found in study products
- •dislike for muffins, fiber bars, or hot cereal
- •BMI <18 or >27
- •diagnosed cardiovascular, renal, or hepatic disease
- •diabetes mellitus (fasting blood sugar >126 mg/dl)
- •cancer in previous 5 years (except basal cell carcinoma of the skin)
- •any gastrointestinal disease or condition
- •recent bacterial infection (< 3 months)
- •recent or concurrent participation in an intervention research study
- •history of drug or alcohol abuse in prior 6 months
- •use of lipid-lowering, anti-hypertensive, or anti-inflammatory steroid medication
- •restrained eaters
- •vegetarians
- •people who eat more than approximately 15 grams of fiber per day
- •women who are pregnant or lactating
- •women with irregular menstrual cycles
结局指标
主要结局
Satiety
时间窗: 0, 15, 30, 45, 60, 90, 120, 180, 215 minutes postprandially
次要结局
- ad libitum food intake(180 minutes postprandially and over 24 hours)
- Ghrelin, polypeptide YY (PYY), and glucagon-like peptide-1 (GLP-1) response(0, 30, 60 minutes postprandially)
- Gastrointestinal tolerance and fecal chemistry(following 7 days of treatment)
- Glucose/Insulin Response(0, 15, 30, 45, 60, 90, 120, 180 minutes postprandially)
研究者
研究点 (2)
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