The Effect of Pregabalin Premedication on Anaesthetic Requirements and Recovery Time After Knee Arthroscopy
试验速览
- 阶段
- 不适用
- 入组人数
- 112
- 主要终点
- Total amount of anesthetics
研究概览
简要总结
Outpatient arthroscopic knee surgery can be performed with general or regional anesthesia. Recent data suggest that spinal and epidural anesthesia require longer discharge times than the newer shorter-acting general anesthetic drugs. Ideal premedication drug should relieve anxiety, produce amnesia and sedation, decrease secretions, prevent nausea and vomiting, have dose sparing effect on the anaesthetic drugs, and suppress pressor response to laryngoscopy and intubation. Recently, gabapentin and pregabalin were suggested as pre-operative drugs to decrease anxiety, stress response to laryngoscopy and post operative pain.
详细描述
112 patients undergoing elective knee arthroscopy will randomly divided into two equal groups, 56 patients each. All patients will receive premedication one hour before the procedure. PG group will receive 150 mg pregabalin and C group will receive placebo. All patients will receive total intravenous anesthesia to achieve optimum working conditions. Intra-operative total amount of anesthetics will be compared in both groups.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Other
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 21 Years 至 50 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients scheduled for elective knee arthroscopy.
- •Patients aged between 21 and 50 years old.
- •Patients with American Society of Anaesthesiologists physical status I or II.
排除标准
- •Patients with known allergy to any drug used in the study.
- •Patients with chronic use of analgesics and/or sedatives.
- •Patients with sleep apnea syndrome.
- •Patients with renal or hepatic dysfunction.
- •Patients with psychiatric disorders.
研究组 & 干预措施
Pregabalin (PG)
Patients will receive 150 mg pregabalin one hour before the procedure.
干预措施: Pregabalin (PG) (Drug)
Control placebo (C)
Patients will receive placebo tablet one hour before surgery.
干预措施: Control placebo (C) (Drug)
结局指标
主要结局
Total amount of anesthetics
时间窗: 45 minutes during the procedure
Total amount of anesthetics used during the procedure.
次要结局
- Patients' satisfaction: satisfaction score(30 minutes after the end of the procedure)
研究者
Dr Ezzeldin Ibrahim
Professor
Menoufia University