Drospirenone and Ethinyl Estradiol Combinations (Yasmin) as Infertility Treatments for Premature Ovarian Failure: a Perspective Follow-up Study.
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 20
- 试验地点
- 1
- 主要终点
- live birth
研究概览
简要总结
Premature ovarian insufficiency (POI) is a life-changing condition that affects women in their reproductive age. There is a lack of reports which focus on how to improve the reproductive outcome of these women who wish to conceive spontaneously or use assisted conception with their own oocytes. However, one could surmise that it is important to lower gonadotropin levels into the physiological range before embarking on any treatment, even if natural conception is the only choice for the woman/couple.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 40 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •premature ovarian failure
- •normal anatomy
- •normal secondary sexual characteristics
- •essential or idiopathic
排除标准
- •chromosomal disorder
- •iatrogenic injury
- •autoimmune diseases
- •infection
- •genetic diseases
研究组 & 干预措施
Yasmin
Pregnancies will occur while the women are taking oral contraceptives (Yasmin). The possible role of exogenous estrogens in sensitizing the granulosa cells to the effect of follicle-stimulating hormone and thereby inducing ovulation and conception in some women with premature ovarian failure is examined.
干预措施: Drospirenone and ethinyl estradiol combination (Yasmin) (Drug)
结局指标
主要结局
live birth
时间窗: 3 years
The event that a FETUS is born alive with heartbeats or RESPIRATION regardless of GESTATIONAL AGE. Such liveborn is called a newborn infant (INFANT, NEWBORN).
次要结局
- clinical pregnancy rate(3 years)
- multiple pregnancy(3 years)
- miscarriage(3 years)
研究者
Yunhai Chuai
Department of Obstetrics and Gynecology, Navy General Hospital, Beijing
Navy General Hospital, Beijing