NCT02160379已完成不适用
Dynamic Effect of Gastrointestinal Hormones on Cerebral Mechanisms Involved in Brain Perception of Food Pictures After Bariatric Surgery
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 31
- 试验地点
- 1
- 主要终点
- Changes of visually-evoked EEG potentials after ingestion of a meal
研究概览
简要总结
This is a cross-sectional study enrolling
- 11 weight-stable, formerly obese female patients 1-5 years after Roux-en-Y gastric Bypass (RYGB)
- 11 age- and weight-matched female subjects
- 10 normal weight (Body Mass Index 19-25 kg/m2) subjects The following measurements will be performed in each participants in basal conditions (after an overnight fast) and after ingestion of a standard meal
- electroencephalographic recordings of visually evoked potential after presentation of food- or non-food pictures
- plasma concentration of metabolites (glucose, fatty acids), glucoregulatory hormones (insulin, glucagon), gastro-intestinal hormones (Gastric Inhibitory Polypeptide (GIP), Glucagon-like Peptide-1 (GLP1), ghrelin,Cholecystokinin (CCK), and bile acids Aims of this observational study are
- to evaluate the effects of RYGB on brain perception of food related visual stimulation
- to search for relationships between RYGB effects on brain responses and gastro-intestinal hormone secretion
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 50 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •good apparent health
- •gender: female
- •age 18-50
- •non-smoker
排除标准
- •diabetes or antidiabetic medication
- •consumption of more than 50g alcohol per week
- •vegetarian or any special diet
结局指标
主要结局
Changes of visually-evoked EEG potentials after ingestion of a meal
时间窗: basal, 120 min postprandial and 240 postprandial
Recording and analysis of visual evoked potentials (VEPs) while patients categorize photographs of foods and non-food kitchen utensils
次要结局
- changes in plasma glucoregulatory status after ingestion of a meal(basal, 90 min postprandial and 180 postprandial)
- changes in plasma triglyceride concentration after ingestion of a meal(basal, 90 min postprandial and 180 postprandial)
- Changes in plasma glucoincretins (GLP1 and GIP) concentrations after ingestion of a meal(basal, 90 min postprandial and 180 postprandial)
- Changes in plasma cholecystokinin concentrations after ingestion of a meal(basal, 90 min postprandial and 180 postprandial)
- Changes in plasma bile acids concentrations after ingestion of a meal(basal, 90 min postprandial and 180 postprandial)
研究者
Luc Tappy, MD
Professor of Physiology
University of Lausanne
研究点 (1)
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