Comparison of Levofloxacin/Colistin with Levofloxacin/high dose Ampicillin-sulbactam infusion in treatment of Ventilator-Associated Pneumonia due to multi drug resistant Acinetobacter
- Conditions
- Ventilator-Associated Pneumonia due to multi drug resistant Acinetobacter.Pneumonia due to other aerobic Gram-negative bacteria
- Registration Number
- IRCT20120703010178N15
- Lead Sponsor
- Shahid Beheshti University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 56
Participant has received mechanical ventilation for > 48 hours
Acute Physiology and Chronic Health Evaluation (APACHE) II score of more than 8
CPIS score >6
ETT culture of MDR acinetobacter (‘MDR Acinetobacter spp.’ will be defined as the isolate resistant to at least three classes of antimicrobial agents as below:all penicillins and cephalosporins (including inhibitor combinations), fluroquinolones, and aminoglycosides.)
History of moderate or severe hypersensitivity reactions to beta-lactam antibiotics or colistin
Kidney injury defined as GFR<30ml/min (day 0 to 3 of the study)
Have received antibiotics for this episode of ventilator-associated pneumonia for more than 96 hours before study medication administration
co-infection in another organs
Acute respiratory distress syndrome
Has any of the following conditions: chest trauma with a fracture of the sternum, ribs, or both
Has lung cancer within the last 2 years
chronic bronchitis with an increase in severity within the last 30 days
tuberculosis on treatment
suspected atypical pneumonia
cystic fibrosis and severe burns to greater than 15% of the body
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 30% Decreasing in CPIS score. Timepoint: Before intervention and 4, 7 , 10 days after intervention. Method of measurement: CPIS score.
- Secondary Outcome Measures
Name Time Method Evaluation of ESR & CPR change in infection treatment. Timepoint: before intervention and 4, 7 , 10 days after intervention. Method of measurement: Laboratory scaling.