Comparison of the safety of two antibiotics - levofloxacin and cefuroxime - when they are used at the end of cataract surgery for the prevention of post-operative infectio
- Conditions
- Cataract surgeryEye DiseasesOther cataract
- Registration Number
- ISRCTN31806847
- Lead Sponsor
- Guys' and St Thomas' Hospital NHS Foundation Trust (UK)
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 30
1. Patients undergoing routine cataract surgery attending the ophthalmology outpatient clinic at St Thomas' Hospital
2. Aged 20-100 years
3. Male or female (of non-childbearing potential)
4. Clinically normal corneal and retinal examination
5. Past ocular history - no history of long-term ocular condition, long-term use of ocular medications or ocular surgery
6. Ability to comply with investigation and follow-up schedule
7. Patients must give informed written consent in order to participate in the study. Non-English speakers will be offered an interpreter. All consents will be witnessed.
1. Unilateral cataract, very dense (brunescent or white) cataracts
2. Significant difference in corneal thickness, endothelial cell count/morphology or macular thickness of greater than 20% at baseline between the two eyes
3. Past ocular history in either eye of:
3.1. Pre-existing ocular conditions (glaucoma, retinal disease, uveitis, corneal disease)
3.2. Previous ocular surgery
3.3. Surgical complications in either eye
4. Diabetes requiring treatment
5. Medications: use of long-term topical eye drops with the exclusion of lubricant drops; use of tamsulosin (known to cause intra-operative floppy iris syndrome)
6. Allergies to fluoroquinolones, cephalosporins
7. Patients unable to give informed consent or are unable to understand the requirements of the trial
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method