Comparison of with and without preoxygenation methods in patients needed procedural sedation and anesthesia

Phase 3

Conditions: Preoxygenation in patients required sedation and anesthesia in ED.

Registration Number: IRCT20210724051964N1

Lead Sponsor: Tehran University of Medical Sciences

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Complete

Sex: All

Target Recruitment: 126

Inclusion Criteria

Patients needed procedural sedation and anesthesia in ED

Exclusion Criteria

Age < 19
Age >65
Pregnant patients
History of ischemic heart disease and Congestive heart disease
History of restrictive or obstructive lung disease
Oxygen saturation less than 92% at rest
Allergy history to egg
Allergy history to Ketamine or Propofol
Systolic blood pressure more than 180 or less than 90 mmhg before procedure
Patients who did not tend to participate in the study
Patients who are unable to sign consent

Study & Design

Study Type: interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Decreased oxygen saturation, which includes the disappearance of the capnograph wave or the drop in oxygen saturation measured by the pulse oximeter. Timepoint: At the beginning, 10, 20 and 30 min after administration of oxygen or air. Method of measurement: Using capnography and pulse oximerty.

Secondary Outcome Measures

Name	Time	Method
Decreasing in blood pressure more than 10% of patient's basic blood pressure. Timepoint: At the beginning , 10 , 20 and 30 minutes after prescription of oxygen or air. Method of measurement: By Blood pressure cuff measurement of monitors.;Variation of end tidal Co2. Timepoint: At the beginning , 10 , 20 and 30 minutes after prescription of oxygen or air. Method of measurement: By Capnograph.;Heart rate decreasing. Timepoint: At the beginning , 10 , 20 and 30 minutes after prescription of oxygen or air. Method of measurement: By monitor at the bedside.;Apnea occurrence. Timepoint: At the beginning , 10 , 20 and 30 minutes after prescription of oxygen or air. Method of measurement: By Capnography and pulse oximetry.