Vanderbilt-Zambia Innovations in Global Health Technologies
Completed
- Conditions
- Malaria Diagnosis
- Registration Number
- NCT02700269
- Lead Sponsor
- Macha Research Trust, Zambia
- Brief Summary
Investigators will evaluate approaches using magnetic bead capture, isolation, and surface tension valve transfer of biomarkers to process capillary blood in order to improve the sensitivity of already approved Rapid Diagnostic Tests (RDTs) for detection of human malaria infection. Results will be compared to those obtained using unenhanced capillary blood specimens directly applied to approved malaria RDTs. Participants seeking care for possible malaria in Zambia will be recruited to enroll in the study.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 278
Inclusion Criteria
- Individuals giving written informed consent for themselves
- Children under the age of 18 for whom a parent or guardian can give consent
- Individuals seeking care or treatment of suspected or possible malaria
- Individuals being screened as a contact of someone with recent malaria
- Other individuals willing to have their blood tested for malaria
Exclusion Criteria
- Anyone over 18 unwilling or unable to provide informed consent
- Anyone under 18 who does not have a parent or guardian to give consent
- Anyone between the age of 12 and 18 who does not give assent
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Enhancement of malaria RDT to detect low levels of P falciparum parasites 5 years The expected outcome of this research project is to enhance the ability of standard malaria RDTs to detect low levels of Plasmodium falciparum malaria in human capillary blood.
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Macha Research Trust
🇿🇲Choma, Zambia