Voxelbox based structural and functional brain mapping in patients with space occupying lesions
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- This study will come to an end when at least 50 analyzable datasets are obtained for rs-fMRI and tb-fMRI (25 for language, 25 for motor).
研究概览
简要总结
The most commonly used imaging modalities in neuro-oncological surgery today are the structural magnetic resonance imaging and the task-based functional magnetic imaging, with the resting-state functional magnetic imaging being less commonly used. However, the latter is in many ways more efficient than the former.
We aim to utilize a resting-state connectomics approach augmented by machine learning, as mentioned below for space occupying lesions. This machine learning-augmented connectomics approach will minimize the risk of resecting functional networks during surgery and improve patient outcomes post-operation.
- To supplement the use of task-based functional magnetic resonance imaging by using resting-state fMRI which utilises machine learning-generated brain masks.
Our machine learning has been trained, on 1200 datasets obtained from the Human Connectome Project, to not only build both task-positive and task-negative networks from preexisting HCP datasets, but also to use those datasets to derive these networks from the patients’ brains. These activations will be validated against those from a task-based functional magnetic imaging for language and motor networks.
- To quantify the extent of network and midline shift in the brain due to mass effect of space occupying lesion.
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 18.00 Year(s) 至 60.00 Year(s)（—）
- 性别
- All
入选标准
- •Brain SOLs
- •Eligible for surgical resection.
排除标准
- •Anyone < 18 and > 60 years of age
- •History of primary neurological disorders including seizure disorders/pre-existing disorders of development and degenerative disorders involving structural changes
- •Primary/pre-existing development and degenerative disorder involving structural changes
- •Primary/pre-existing Movement, Vision and speech disorders
- •Surgery in adjunct with cranial radiotherapy
- •Follow-up cases
- •Patients with contraindications to magnetic resonance imaging scanning
- •Pregnant women
- •Cases of meningioma
- •Non- compliance with fMRI protocol
- •Clinical symptoms not matching with SOL.
结局指标
主要结局
This study will come to an end when at least 50 analyzable datasets are obtained for rs-fMRI and tb-fMRI (25 for language, 25 for motor).
时间窗: The study is expected to take 12 months.
次要结局
- There are no secondary outcomes.
- There are no secondary outcomes.(N/A)
研究者
Ullas V Acharya
Manipal Hospital