DRKS00030637招募中不适用
Short-chain carnitines as potential biomarkers in depressed adolescents and their associations with aberrant (neuro)immunological and endocrinological parameters
ehrstuhl für Kinder- und Jugendpsychiatrie und -psychotherapie der Universität Regensburg am Bezirksklinikum Regensburg (medbo)0 个研究点目标入组 70 人开始时间: 2022年11月2日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 70
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 11 Years 至 18 Years（—）
- 性别
- All
入选标准
- •Sufficient comprehension of the German language
- •- Patient Cohort (PC):
- •Fulfillment of ICD-10 criteria regarding the classification of depressive disorders under F32. or F33. or F43.21 based on expert judgment;
- •In addition, fulfillment of the Major Depressive Disorder criteria in the MINI-Kid (Mini-International Neuropsychiatric Interview for Children and Adolescents).
- •- Patient Cohort (PC):
- •Outpatient, partial or full inpatient connection within the child/adolescent psychiatric care network either at the Clinic for Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy (KJPP) of the University of Regensburg at the District Clinic Regensburg or at the child and adolescent psychiatric as well as social psychiatric practice Dr. med Matthias Niebler in Neumarkt/Opf.
- •- Informed consent of the test persons and their legal guardians
排除标准
- •- Acute neurological or somatic diseases with long-term influence on endocrinological, metabolic or inflammatory regulatory circuits, which occurred less than six months ago
- •- Pre-existing chronic endocrinologic, neurologic, autoimmune, or autoinflammatory diseases
- •- Acute febrile flu-like infections with fever at the time of blood draw
- •- medically confirmed needle phobia
- •- psychiatric comorbidities with a high burden of disease and severe manifestations, specifically clinical pictures such as schizophrenia, autism spectrum disorders (ASD), Borderline Personality Disorder (BPD) and eating disorders requiring inpatient treatment
- •- Acute psychiatric condition that could impair the patient's/proband's ability to give consent
- •- Consumption of substances listed in the current (as of 08/2022) version of the BtMG within the last four weeks
- •- Harmful (ICD-10: F10.1) alcohol intake within the last four weeks or abusive (ICD-10: F10.2) alcohol consumption within the last three months
- •- Harmful (ICD-10: F17.1) tobacco consumption within the past four weeks or abusive (ICD-10: F17.2) tobacco consumption within the past three months
- •- Consumption of alcohol or nicotine in the last 24 h before blood sampling
- •- Long-term pharmacotherapy with antidepressant intent, discontinuation of which was less than three months ago
- •- Long-term therapy (> 1 month) less than four weeks ago with pharmaceuticals that exert influence on metabolome, endocrine or inflammatory axis, especially systemic steroid therapy, statin therapy, therapy with immunomodulatory/immunosuppressive pharmaceuticals;
- •Exception: hormonal contraception
- •- current anti-infective therapy at the time of blood collection
- •- Pregnancy
- •- Known intellectual impairment (IQ<80)
- •- lack of consent
研究者
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