Effect of add-on therapy with Ranolazine on reducing tissue ischemia and improvement of clinical outcome in patients with severe bur
- Conditions
- Burn.Burn and corrosion of head, face, and neck
- Registration Number
- IRCT20210524051384N10
- Lead Sponsor
- Rasht University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 78
Age range from 18 to 65 years
Acute burn in less than 6 hours
Total body surface area (TBSA) between 20 - 50%
patients of American Society of Anesthesiologists (ASA) class I (a normal healthy person)
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Having severe hypertension blood pressure (BP) = 160/90 mmHg or systolic pressure below 100 mmHg
Ischemic changes in electrocardiogram (ECG)
Heart rate less than 70 beats per minute
Pregnant women
Peripheral vascular disease
Presence of inhalation injury
Presence of burn shock (including decreased cardiac output, increased vascular resistance, hypovolemia and hypoperfusion following severe burns)
Electrical and chemical burns
Kidney or liver failure caused by burns (according to the kidney and liver metabolism of the drug)
Presence of drug interactions with the patient's previous medications
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Graft to TBSA (total body surface area) percent ratio. Timepoint: At discharge. Method of measurement: Measurements based on Wallace criteria.;Mortality. Timepoint: At discharge. Method of measurement: Based on the clinical outcome recorded in the patients' files.
- Secondary Outcome Measures
Name Time Method ength of hospital stay. Timepoint: At discharge. Method of measurement: Based on patient's file.;SIRS (Systemic inflammatory response syndrome). Timepoint: On the 1st, 3rd and 7th days of hospitalization. Method of measurement: Based on criteria including temperature, heart rate, respiratory rate, and WBC (white blood cell) count.;Infection. Timepoint: On the 1st, 3rd and 7th days of hospitalization. Method of measurement: Based on clinical decision of doctor.