Relative Sarcopenia and Cardiometabolic Risk in Young Adults With Obesity

Completed

• Conditions: Overweight and Obesity; Insulin Resistance
• Interventions: Procedure: Cardiopulmonary exercise test (CPET)

• Registration Number: NCT04195061
• Lead Sponsor: Massachusetts General Hospital

Brief Summary

The goal of this research study is to learn more about the hormones that muscles make during exercise, and if those hormones are associated with type 2 diabetes risk in adults who are overweight or obese. Participants will undergo exercise testing on an upright bicycle, with blood samples taken for muscle hormones before and after exercise. The hypothesis is that adults with overweight/obesity and insulin resistance will have an impaired muscle hormone profile in response to exercise compared to adults with overweight/obesity who are not insulin resistant.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2019-12-09
• Study First Submitted QC: 2019-12-09
• Study First Posted: 2019-12-11
• Study Start: 2019-12-12
• Primary Completion: 2021-11-17
• Study Completion: 2021-11-17
• Results First Submitted: 2023-02-07
• Status Verified: 2024-01
• Results First Submitted QC: 2024-01-19
• Last Update Submitted: 2024-01-19
• Results First Posted: 2024-01-30
• Last Update Posted: 2024-01-30

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 28

Inclusion Criteria

• Previously enrolled in protocol 2004P000013 or protocol 2012P002276, which had overweight or obesity as inclusion criteria
• Ability to walk up 3 flights of stairs and 3 city blocks (to ensure ability to complete exercise testing)

Exclusion Criteria

• Unstable heart or lung disease
• Exercise >150 minutes/week
• Participation in college sports

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Cardiopulmonary exercise testing	Cardiopulmonary exercise test (CPET)	-

Primary Outcome Measures

Name	Time	Method
Percent Change in Serum Myostatin Levels From Pre- to 3 Hours Post-exercise	Pre- to 3 hours post-exercise	Percent change in serum myostatin levels from pre- to 3 hours post-cardiopulmonary exercise test

Secondary Outcome Measures

Name	Time	Method
Percent Change in Serum Myostatin Levels From Immediately Post to 2 Hours Post-exercise	Immediately post to 2 hours post-exercise	Percent change in serum myostatin levels from immediately post to 2 hours post-cardiopulmonary exercise test
Percent Change in Serum Myostatin Levels From Pre- to 2 Hours Post-exercise	Pre- to 2 hours post-exercise	Percent change in serum myostatin levels from pre- to 2 hours post-cardiopulmonary exercise test

Trial Locations

Locations (1)

Massachusetts General Hospital; 🇺🇸 Boston, Massachusetts, United States