Cortical-Basal Ganglia Speech Networks

Not Applicable

Recruiting

• Conditions: Parkinson Disease; Essential Tremor; Dystonia
• Interventions: Other: electrophysiological data collection

• Registration Number: NCT04286308
• Lead Sponsor: Massachusetts General Hospital

Brief Summary

In this research study the researchers want to learn more about brain activity related to speech perception and production.

Detailed Description

Speech production is disrupted in a number of neurological diseases that involve the basal ganglia, including Parkinson's disease (PD) and dystonia. The investigators will use a novel experimental approach and combination of analytic techniques to elucidate the contribution of neural activity in cortical-basal ganglia circuits to the hierarchical control of speech production, in subjects undergoing deep brain stimulation surgery.

Study Timeline

• Study First Submitted: 2020-01-08
• Study First Submitted QC: 2020-02-25
• Study First Posted: 2020-02-27
• Study Start: 2020-10-01
• Status Verified: 2024-06
• Last Update Submitted: 2024-06-26
• Last Update Posted: 2024-06-27
• Primary Completion: 2025-02
• Study Completion: 2026-02

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 80

Inclusion Criteria

1. Subjects scheduled for DBS implantation, as determined by the clinical multidisciplinary movement disorders board with definitive diagnosis of Parkinson's disease, essential tremor or dystonia.
2. Subjects able to provide informed consent and comply with task instructions.
3. Subjects 18-85 years old

Exclusion Criteria

1. Subjects with reported hearing loss.
2. Non-English-speaking subjects

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Brain signal data collection	electrophysiological data collection	Brain signal data collection at the time of deep brain stimulation (DBS) surgery.

Primary Outcome Measures

Name	Time	Method
The number of subjects providing the interpretable speech related electrophysiological data collection.	Duration of single DBS surgery	The number of subjects providing the interpretable speech related electrophysiological data during DBS surgery.

Trial Locations

Locations (1)

Massachusetts General Hospital; 🇺🇸 Boston, Massachusetts, United States