IRM Cardiaque en Respiration Libre Pour Des Patients Atteints de Dystrophinopathie sévère
- Conditions
- Duchenne or Severe Becker Myopathy
- Registration Number
- NCT02078076
- Lead Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
- Brief Summary
Clinical, prospective and monocentric study aiming at assessing the feasibility of fibrosis detection and quantification (and of function assessment) during MRI without breath-holds in a population of adults and children with Duchenne myopathy.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 22
- Dystophinopathy (Duchenne or severe Becker)
- >8yo
- with social insurance
- informed consent
- arythmia
- impossibility to undergo an MRI (pacemaker, ....)
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Primary Outcome Measures
Name Time Method Number of exams correctly acquired (feasabiliy of the exam) after the last inclusion Was it possible to acquire the whole examination for every patient ?
Number of exams allowing a qualitative assessment of images by the physician after the last MRI exam The image quality allows a qualitative diagnosis ?
Number of exams allowing a quantitative assessment of the diagnosis after the last MRI examination Did the image quality allow a quantitative assessment of the diagnosis ?
- Secondary Outcome Measures
Name Time Method Number of anatomic cardiac segments with significant fibrosis according to the assessment methods (conventional LGE, qualitative detection with GRICS, and quantiative measure with GRICS) after the last inclusion correlation between fibrosis information (conventional LGE, qualitative detection with GRICS, and quantiative measure with GRICS)
Number of cardiac segments with fibrosis and/or regional dysfunction after the last inclusion Correlation between fibrosis and regional function for each cardiac segment
Trial Locations
- Locations (1)
Service de médecin nucléaire / CHU Nancy Brabois
🇫🇷Vandoeuvre, France
Service de médecin nucléaire / CHU Nancy Brabois🇫🇷Vandoeuvre, France