Correlation Between Salivary Cortisol and Free Serum Cortisol Compared to Total Serum Cortisol in MICU Patients With Septic Shock
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- Salivary cortisol
研究概览
简要总结
The purpose of the study is:
- to correlate salivary cortisol to free serum cortisol (as salivary cortisol is considered to be almost complete free cortisol) and,
- to correlate free serum cortisol to total serum cortisol levels
Both in patients with septic shock (severe sepsis requiring vasopressors).
We believe that:
- total serum cortisol does not correlate with free serum cortisol in patient with septic shock and,
- that salivary cortisol correlates with free serum cortisol and can be used to determine the level of free serum cortisol.
详细描述
Free serum cortisol is considered the active hormone.
In patients with septic shock only the total serum cortisol level is available, however, the free cortisol level can be normal despite a low total cortisol level due to changes in the serum protein.
The hormone can be replaced improperly in these patients and contribute to poor outcome in septic shock.
We are studying adult MICU patients with septic shock who are not receiving corticosteroid replacement.
This study does not include any intervention.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Adult patients with septic shock
排除标准
- •Corticosteroid replacement
- •Blood in mouth
结局指标
主要结局
Salivary cortisol
时间窗: one year
salivary cortisol in mg/dL
次要结局
未报告次要终点
研究者
Rosa Estrada Y Martin
Associate Professor
The University of Texas Health Science Center, Houston