Efficacy and Safety of Tanimilast in Asthmatics uNcontrolled on ICS-containinG backgrOund Maintenance Therapy

Phase 2

Recruiting

• Conditions: Uncontrolled Asthma

• Registration Number: NCT06029595
• Lead Sponsor: Chiesi Farmaceutici S.p.A.

Brief Summary

The purpose of this study is to evaluate the efficacy and safety of CHF6001 (Tanimilast) as add-on to maintenance of inhaled corticosteroids in combination with Long-acting ß2-agonists in the target patient population. (TANGO)

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2023-08-31
• Study First Submitted QC: 2023-09-07
• Study First Posted: 2023-09-08
• Study Start: 2023-11-26
• Status Verified: 2024-04
• Last Update Submitted: 2024-04-09
• Last Update Posted: 2024-04-10
• Primary Completion: 2025-12-18
• Study Completion: 2025-12-18

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 464

Inclusion Criteria

1. Subject's written informed consent
2. Male or female subjects aged ≥18 and ≤75 years
3. A documented history of physician-diagnosed asthma for at least 1 year and with diagnosis before the age of 50 years
4. Stable asthma therapy: a stable maintenance treatment with medium to high dose of inhaled corticosteroids plus long acting β2 agonists for at least 3 months prior to screening
5. A prebronchodilator FEV1 ≤80% of the predicted normal value
6. Bronchodilator responsiveness after inhalation of salbutamol or equivalent
7. Evidence of poorly controlled or uncontrolled asthma as based on an ACQ-7 score ≥1.5
8. History of asthma exacerbations : at least 1 asthma exacerbation leading to hospitalisation or 2 or more asthma exacerbations within the last 12 months
9. A cooperative attitude and ability to use inhalers and to comply with study procedures

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Exclusion Criteria

1. e-Diary completion compliance <75% during run-in
2. History of near fatal asthma or of a past hospitalisation for asthma in intensive care unit
3. Recent exacerbation or respiratory tract infection within 4 weeks prior to screening visit or during the run-in period
4. Subjects using systemic corticosteroids medication in the 4 weeks or slow-release corticosteroids in the 12 weeks prior to randomisation
5. Asthma requiring use of biologics
6. Respiratory disorders other than asthma: subjects with known respiratory disorders other than asthma
7. Subjects with a history of lung volume resection
8. Current smokers, ex-smokers with a smoking history of ≥10 pack-years or current use of inhaled or oral cannabis products.
9. Subjects with cancer or history of cancer
10. Subjects with cardiovascular diseases
11. Subjects with any abnormal and clinically significant 12-lead ECG
12. Subjects with previous medical history, evidence of an uncontrolled intercurrent illness, or any clinically relevant abnormal findings in haematology, clinical chemistry, or urinalysis
13. Subjects with a diagnosis of depression, generalised anxiety disorder, suicidal ideation or behaviour
14. Patients mentally or legally incapacitated or patients accommodated in an establishment
15. Subjects with liver diseases
16. Drugs with hepatoxicity potential
17. Subjects with contra-indications to IMPs:
18. Subjects with history alcohol/drug abuse
19. Subjects with major surgery in the 3 months prior to screening visit or planned during the trial
20. Subjects treated with non-potassium sparing diuretics, nonselective β-blocking drugs, quinidine, quinidine like anti-arrhythmic, or any medication with a QTc prolongation potential or a history of QTc prolongation
21. Subjects treated with monoamine oxidase inhibitors (MAOIs) and tricyclic anti-depressants
22. Subjects receiving any therapy that could interfere with the study drugs
23. Participation in another investigational trial
24. Documented coronavirus disease 2019 (COVID-19) diagnosis within the last 2 weeks
25. Subjects having received a vaccination within 2 weeks prior to screening or during the run-in period.
26. For females only: pregnant or lactating women

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
Number of Asthma exacerbation over 52 weeks of treatment	Over 52 weeks	Number of Asthma exacerbation over 52 weeks of treatment (Asthma exacerbations defined as severe event with worsening of asthma requiring at least 3 days of SCS use with or without emergency visit or hospitalization)

Secondary Outcome Measures

Name	Time	Method
Number of asthma exacerbation and asthma worsening over 52 weeks of treatment	Up to 52 weeks	Asthma exacerbations defined as severe event with worsening of asthma requiring at least 3 days of SCS use with or without emergency visit or hospitalization; Asthma worsening defined as moderate asthma exacerbation.
ACQ-7 responders	week 4, week 26 and week 52	ACQ-7 responders at Week 4, Week 26 and Week 52 (i.e., subjects showing improvement from baseline in ACQ-7 score of ≥0.5 units);
Change from baseline in ACQ-7 and ACQ-6	week 4, week 26 and week 52	Change from baseline in ACQ-7 and ACQ-6 at Week 4, Week 26 and Week 52
Change from baseline in Mini-AQLQ	week 4, week 26 and week 52	Change from baseline in Mini-AQLQ at Week 4, Week 26 and Week 52
Change from baseline (run-in period) to each inter-visit period and to the entire treatment period in pre dose morning/evening PEF;	Up to 52 weeks
Change from baseline in pre-dose FEV1	week 4, week 26 and week 52	Change from baseline in pre-dose FEV1 at Week 4, Week 26 and Week 52;
Time to first asthma exacerbation;	Up to 52 weeks	Asthma exacerbations defined as severe event with worsening of asthma requiring at least 3 days of SCS use with or without emergency visit or hospitalization
Time to first asthma exacerbation or asthma worsening	Up to 52 weeks	Asthma exacerbations defined as severe event with worsening of asthma requiring at least 3 days of SCS use with or without emergency visit or hospitalization; Asthma worsening defined as moderate asthma exacerbation.
Change from baseline in pre-dose FVC	Week4, Week 52 and Week 26	Change from baseline in pre-dose FVC at Week4, Week 52 and Week 26;
Change from baseline to each inter-visit period and to the entire treatment period in the average rescue medication use (number of puffs/day) and asthma symptoms score	Up to 52 weeks
Change from baseline to each inter-visit period and to the entire treatment period in the percentage of rescue medication-free days, asthma symptoms-free days and asthma control days.	Up to 52 weeks

Trial Locations

Locations (195)

Site 032027- Centro de Medicina Respiratoria; 🇦🇷 Argentina, Argentina

032021 - Centro De Investigaciones Medicas Mar Del Plata; 🇦🇷 Buenos Aires, Argentina

Site 032024 -CEMLO- Consultorio Medico CEMLO LOBOS; 🇦🇷 Buenos Aires, Argentina

Site 032032 - Hospital Italiano de Buenos Aires (HIBA); 🇦🇷 Buenos Aires, Argentina

Site 032025 - Sala Mignaburu; 🇦🇷 Buenos Aires, Argentina

Site 032029 - Hospital de Alta Complejidad del Bicentenario de Esteban Echeverría; 🇦🇷 Buenos Aires, Argentina

Site 032031 - Centro de Investigaciones Metabolicas (CINME) S.A.; 🇦🇷 Buenos Aires, Argentina

Site 032026 - IAAER-Instituto de Asma, Alergia y Enfermedades Respiratorias; 🇦🇷 Corrientes, Argentina

Site 032004 - CARE - Centro de Alergia y Enfermedades Respiratorias; 🇦🇷 Buenos Aires, Argentina

Site 032014 - Instituto de Investigaciones en Alergia y Enfermedades Respiratorias (INAER); 🇦🇷 Buenos Aires, Argentina

Site 032023 - Respira Salud Clinica Integral; 🇦🇷 Mendoza, Argentina

032016 - Instituto Medico de la Fundacion Estudios Clinicos; 🇦🇷 Santa Fe, Argentina

Site 032028 - Instituto De Investigaciones Clnicas De Rosario; 🇦🇷 Santa Fe, Argentina

Site 100025 - Dr. Filip Shterev - Individual ambulatory practice for specialized medical care; 🇧🇬 Plovdiv, Bulgaria

Site 100028 - Medical Center Smolyan Clinical Research; 🇧🇬 Smolyan, Bulgaria

Site 268007 - LTD "Tbilisi State Medical University and Ingorokva High Medical Technology University Clinic"; 🇬🇪 Tbilisi, Georgia

Site 616022 - Makowskie Centrum Medyczne Hamernia Sp. z o.o.; 🇵🇱 Maków Podhalański, Poland

Site 032020 - Instituto Especialidades de la Salud Rosario - Clinica del Torax; 🇦🇷 Santa Fe, La, Argentina

Site 032008 - Mautalen Salud e Investigacion; 🇦🇷 Ciudad Autonoma de Buenos Aires, Argentina

Site 032003 -Fundacion Respirar (Centro Medico Dra. De Salvo) - Instituto Argentino de Investigaciones Clinicas (IAIC) S.R.L; 🇦🇷 Ciudad de Buenos Aires, Argentina

Site 032005 - National University of Cordoba - Rusculleda Foundation - Instituto DAMIC; 🇦🇷 Córdoba, Argentina

Site 032001 - Instituto de Enfermedades Respiratorias e Investigacion Medica- IERIM; 🇦🇷 Florencio Varela, Argentina

Site 032010 - Centro Platense en Investigaciones Respiratorias - CEPIR; 🇦🇷 La Plata, Argentina

Site 032013 - Centro de Investigacion Medico Lanus-CIMEL CHAHIN CHAHIN S.A; 🇦🇷 Lanús, Argentina

Site 032006 -Institute Fundacion Enfisema - Instituto Ave Pulmo; Hospital Privado de Comunidad (HPC); 🇦🇷 Mar Del Plata, Argentina

Site 032021 - Centro De Investigaciones Medicas Mar Del Plata; 🇦🇷 Mar Del Plata, Argentina

Site 032002 -Consultorios Medicos Dr Isaac Scherbovsky - Fundacion Scherbovsky; 🇦🇷 Mendoza, Argentina

Site 032009 - Centro Medico INSARES; 🇦🇷 Mendoza, Argentina

Site 032011 - Centro Privado de Medicina Respiratoria de Parana - CPMR; 🇦🇷 Parana, Argentina

Site 032016 - Centro Respiratorio Infantil; 🇦🇷 Rosario, Argentina

Site 032019 - Servicio de Investigacion de Patologias Alergicas del Instituto ABC - Rosario; 🇦🇷 Rosario, Argentina

Site 032018 - Instituto de Investigaciones en Patologias Respiratorias; 🇦🇷 San Miguel De Tucumán, Argentina

Site 032015 - Fundacion de Estudios Clinicos de Consultorio Integrados Rosario; 🇦🇷 San Miguel De Tucumán, Argentina

Site 032022 - Clinica Mayo de Urgencias Medicas Cruz Blanca SRL; 🇦🇷 San Miguel De Tucumán, Argentina

Site 032012 - Instituto Del Buen Aire; 🇦🇷 Santa Fe de la Vera Cruz, Argentina

Site 100012 - Medical Center Asklepii OOD; 🇧🇬 Dupnitsa, Bulgaria

Site 032017 - Centro Medico de Enfermedades Respiratorias (CEMER); 🇦🇷 Vicente López, Argentina

Site 100005 _MHAT Dr. Tota Venkova AD; 🇧🇬 Gabrovo, Bulgaria

Site 100011 - Medical Center Pulmo-2018 EOOD; 🇧🇬 Haskovo, Bulgaria

Site 100021 - MC Zdrave 1; 🇧🇬 Kozloduy, Bulgaria

Site 100017 - MHAT Sveti Panteleymon EOOD; 🇧🇬 Plovdiv, Bulgaria

Site 100003 - """DCC 1 - Pernik"" EOOD"; 🇧🇬 Pernik, Bulgaria

Site 100010 - Medical Center FAMA; 🇧🇬 Plovdiv, Bulgaria

Site 100024 - Medical center Respiro; 🇧🇬 Razgrad, Bulgaria

Site 100006 _ Ambulatory For Specialized Outpatient Medical Care - Individual Practice - Dr. Nikolay Evgeniev Ruse Ltd; 🇧🇬 Ruse, Bulgaria

Site 100014 -SBALPFZ - Ruse EOOD; 🇧🇬 Ruse, Bulgaria

Site 100029 - DCC 1 Sevlievo; 🇧🇬 Sevlievo, Bulgaria

100001 -5th MHAT - Sofia EAD; 🇧🇬 Sofia, Bulgaria

Site 100004 - MHAT Dr. Ivan Seliminski AD; 🇧🇬 Sliven, Bulgaria

Site 100028 - Smolyan Clinical Research Center; 🇧🇬 Smolyan, Bulgaria

Site 100002 _MHAT St. Ekaterina Dimitrovgrad; 🇧🇬 Sofia, Bulgaria

Site 100001- 5th MHAT - Sofia EAD; 🇧🇬 Sofia, Bulgaria

Site 100008 _Diagnostic Consultative Center Convex Ltd; 🇧🇬 Sofia, Bulgaria

Site 100013 - MHAT Lyulin EAD; 🇧🇬 Sofia, Bulgaria

Site 100018 - Medical Center Excelsior Ltd; 🇧🇬 Sofia, Bulgaria

Site 100019 - Aleksandrovska University Hospital; 🇧🇬 Sofia, Bulgaria

Site 100020 -Medical Centre N. I. Pirogov EOOD; 🇧🇬 Sofia, Bulgaria

Site 100023 - University First Multiprofile Hospital for Active treatment-Sofia EAD; 🇧🇬 Sofia, Bulgaria

Site 100026 - Military Medical Academy (MMA); 🇧🇬 Sofia, Bulgaria

Site 100030 - Medical Center Hera EOOD; 🇧🇬 Sofia, Bulgaria

Site 100009 - Medical Center Kissiovi; 🇧🇬 Varna, Bulgaria

Site 100027 - Medical Center Research Expert; 🇧🇬 Varna, Bulgaria

Site 100007 _SHATPPD Vratsa; 🇧🇬 Vratsa, Bulgaria

Site 203001 -MUDr. I. Cierna Peterova s.r.o.; 🇨🇿 Brandýs Nad Labem, Czechia

Site 203008 - Fakultni nemocnice Brno; 🇨🇿 Brno, Czechia

Site 203002 - MediTrial s.r.o.; 🇨🇿 Jindřichův Hradec, Czechia

Site 203009 - Alergologie Nemcova s.r.o; 🇨🇿 Liskovec, Czechia

203004 -Nemocnice Mesice; 🇨🇿 Mesice, Czechia

Site 203003 - Plicni Stredisko Teplice, s.r.o.; 🇨🇿 Teplice, Czechia

Site 203005 - Ambulance Pneumologie a Ftizeologie; 🇨🇿 Varnsdorf, Czechia

268007 - TSMU & Ingorokva High Medical Technologies University Clinic; 🇬🇪 Tbilisi, Georgia

Site 268001 - Chapidze Emergency Cardiology Center; 🇬🇪 Tbilisi, Georgia

Site 268002 - JSC German Hospital; 🇬🇪 Tbilisi, Georgia

Site 268003 - French Joint Hepatology Clinic Hepa; 🇬🇪 Tbilisi, Georgia

Site 268004 - LTD Helsicore; 🇬🇪 Tbilisi, Georgia

Site 276004 - RCMS; 🇩🇪 Berlin, Germany

Site 268005 - LLC Medi Club Georgia; 🇬🇪 Tbilisi, Georgia

Site 268006 - The Firsts University Clinic of Tbilisi State Medical University; 🇬🇪 Tbilisi, Georgia

Site 276012 - Institut fuer Allergie- und Asthmaforschung Berlin; 🇩🇪 Berlin, Germany

Site 276013 - MECS Research; 🇩🇪 Berlin, Germany

Site 276010 - Office of Dr. Thomas Ginko, MD; 🇩🇪 Bonn, Germany

Site 276014 - MECS Cottbus GmbH; 🇩🇪 Cottbus, Germany

Site 276019 - Praxis Dr. Eckhardt; 🇩🇪 Delitzsch, Germany

Site 276003 - ME Clinical Respiratory Research Hamburg; 🇩🇪 Hamburg, Germany

Site 276007 - IKF Institut fuer klinische Forschung Frankfurt; 🇩🇪 Frankfurt am Main, Germany

Site 276008 - Office of Dr. med. Claus Keller MD; 🇩🇪 Frankfurt am Main, Germany

Site 276002 - Pneumologicum im Suedstadtforum - Hannover; 🇩🇪 Hannover, Germany

Site 276015 - Velocity Clinical Research Hamburg GmbH; 🇩🇪 Hamburg, Germany

Site 276009 - Velocity Clinical Research Leipzig GmbH; 🇩🇪 Leipzig, Germany

Site 276011 - POIS Sachsen GmbH; 🇩🇪 Leipzig, Germany

Site 276020 - BAG Prof. Gerhard Hoheisel/Dr. Andreas Bonitz Praxis für Pneumologie und Allergologie-Studienzentrum; 🇩🇪 Leipzig, Germany

Site 276006 - IKF Pneumologie Mainz, Helix Medical Excellence Center Mainz; 🇩🇪 Mainz, Germany

Site 276017 - Office of Dr. Christian Schlenska MD; 🇩🇪 Peine, Germany

Site 276001 - Studienzentrum Muenchen-West; Gemeinschaftspraxis fuer Lungen- und Bronchialheilkunde Prof. Dr. med. Rainald Fischer und Dr. med. Michael Baborka; 🇩🇪 Muenchen, Germany

Site 276021 - Pneumologische Gemeinschaftspraxis Rheine; 🇩🇪 Rheine, Germany

Site 276022 - Universitaetsmedizin Rostock; 🇩🇪 Rostock, Germany

Site 276005 - Lungenzentrum Ruhr - Praxis fuer Lungenheilkunde; 🇩🇪 Witten, Germany

Site 276016 - Praxisgemeinschaft in Saalfeld - HNO; 🇩🇪 Saalfeld /Saale, Germany

Site 276018 - Siteworks Prufzentrum Schleswig-RespiRatio; 🇩🇪 Schleswig, Germany

Site 348002 - Clinexpert SMO; 🇭🇺 Budapest, Hungary

Site 348003 - ClinTrial-Kenezy Hospital Institute of Clinical Pharmacology Infectology and Allergology; 🇭🇺 Debrecen, Hungary

Site 348006 - Bajcsy-Zsilinszky Hospital; 🇭🇺 Budapest, Hungary

Site 348001 - Koch Robert Korhaz es Rendelointezet; 🇭🇺 Edeleny, Hungary

Site 348005 - Szalay Janos Rendelointezet; 🇭🇺 Hajdúnánás, Hungary

Site 348004 - INFER-MED Kft. Da Vinci Maganklinika; 🇭🇺 Pecs, Hungary

Site 380005 - Ospedale Fatebenefratelli Isola Tiberina Gemelli Isola; 🇮🇹 Roma, Italy

Site 380006 - Azienda Ospedaliero Universitaria Pisana - Stabilimento Ospedaliero di Santa Chiara; 🇮🇹 Pisa, Italy

Site 380002 - AOU-S.Orsola-Malpighi - Universita degli Studi di Bologna; 🇮🇹 Bologna, Italy

Site 380003 - Azienda Ospedaliero Universitaria OO RR di Foggia; 🇮🇹 Foggia, Italy

Site 380001 - SC Pneumologia -Fondazione IRCCS Policlinico San Matteo; 🇮🇹 Pavia, Italy

Site 380004 - Fondazione Salvatore Maugeri I.R.C.C.S. - Istituto Scientifico di Tradate; 🇮🇹 Tradate, Italy

Site 410012 - Chungbuk National University Hospital (CBNUH); 🇰🇷 Cheongju-si, Korea, Republic of

Site 410010 - Yeungnam University Medical Center; 🇰🇷 Daegu, Korea, Republic of

Site 410003 - Hallym University Sacred Heart Hospital; 🇰🇷 Anyang-si, Korea, Republic of

Site 410014 - The Catholic University of Korea, Incheon St. Mary's Hospital; 🇰🇷 Incheon, Korea, Republic of

Site 410004 - Jeonbuk National University Hospital; 🇰🇷 Jeonju, Korea, Republic of

Site 410007 - Kangbuk Samsung Hospital; 🇰🇷 Seoul, Korea, Republic of

Site 410013 - Chung-Ang University College of Medicine - Chung-Ang University Hopital (CAUH); 🇰🇷 Seoul, Korea, Republic of

Site 410009 - Ajou University Hospital; 🇰🇷 Suwon-si, Korea, Republic of

Site 410011 - Yonsei University Wonju Severance Christian Hospital; 🇰🇷 Wonju, Korea, Republic of

Site 428008 - Dubultu Poliklinika; 🇱🇻 Jurmala, Latvia

Site 428005 - Balvi and Gulbene hospital union; 🇱🇻 Balvi, Latvia

Site 428001 - Pauls Stradins Clinical University Hospital; 🇱🇻 Riga, Latvia

Site 428003 - Latvian University Medical Postgraduate Institute; 🇱🇻 Riga, Latvia

Site 428006 - RiGa 1st Hospital; 🇱🇻 Riga, Latvia

Site 428002 - Consilium Medicum SIA; 🇱🇻 Riga, Latvia

Site 428007 - SIA RAKUS; 🇱🇻 Riga, Latvia

Site 440002 - Hospital of Lithuanian University of Health Sciences Kauno klinikos; 🇱🇹 Kaunas, Lithuania

Site 440007 - Republic Hospital Of Klaipeda (Respublikine Klaipedos ligonine); 🇱🇹 Klaipeda, Lithuania

Site 440005 - PI Republican Siauliai Hospital; 🇱🇹 Siauliai, Lithuania

Site 440001 - Viesoji Istaiga Antakalnio poliklinika; 🇱🇹 Vilnius, Lithuania

Site 616011 - Centrum Medycyny Oddechowej, Mroz Spolka Jawna; 🇵🇱 Białystok, Poland

Site 440003 - LSMU Kauno ligoninė (Kaunas Hospital of the Lithuanian University of Health Sciences); 🇱🇹 Kaunas, Lithuania

Site 440006 - CD8 Klinika; 🇱🇹 Kaunas, Lithuania

Site 616017 - NZOZ Przychodnia Vitamed; 🇵🇱 Bydgoszcz, Poland

Site 616024- Mital Site; 🇵🇱 Elblag, Poland

Site 616015 - Centrum Medyczne CLW-MED Aneta Cichomska i Joanna Luka-Wendrowska; 🇵🇱 Grudziądz, Poland

Site 616020 - Pro Familia Altera Sp. z o.o.; 🇵🇱 Katowice, Poland

Site 616001 - Malopolskie Centrum Alergologii Sp z o.o; 🇵🇱 Krakow, Poland

Site 616018 - Prywatna Praktyka Lekarska Adam Śmiałowski - Intermed Ksawerów; 🇵🇱 Ksawerow, Poland

Site 616008 - Centrum Alergologii Specjalistyczna Przychodnia Alergologiczna; 🇵🇱 Lublin, Poland

Site 616025 - MS Pneumed Janusz Milanowski, Katarzyna Szmygin-Milanowska Spolka Jawna; 🇵🇱 Lublin, Poland

616007 - ETG Lodz; 🇵🇱 Lodz, Poland

Site 616010 - Centrum Diagnostyczno-Terapeutyczne (CDT) Medicus Sp.z o.o.; 🇵🇱 Lubin, Poland

Site 616013 - Ostrowieckie Centrum Medyczne Spolka Cywilna Anna Olech-Cudzik, Krzysztof Cudzik; 🇵🇱 Ostrowiec Świętokrzyski, Poland

Site 616006 - Centrum Alergologii Teresa Hofman Sp.z.o.o; 🇵🇱 Poznan, Poland

Site 616019 - Alergologia Plus; 🇵🇱 Poznan, Poland

Site 616002 - Niepubliczny Zaklad Opieki Zdrowotnej (NZOZ) Allmed - Regionalne Centrum Leczenia Chorob Pluc i Alergii; 🇵🇱 Piekary Śląskie, Poland

Site 616023 - Specjalistyczna Przychodnia Lekarska Alergo-Med Sp. z o.o; 🇵🇱 Poznan, Poland

Site 616014 - Pawlukiewicz Malgorzata Prywatny Gabinet Lekarski; 🇵🇱 Rzeszow, Poland

Site 616005 - Niepubliczny Zaklad Opieki Zdrowotnej (NZOZ) - Poradnia Chorob Pluc; 🇵🇱 Slupsk, Poland

Site 616016 - Michal Bogacki Dobrostan; 🇵🇱 Wroclaw, Poland

Site 616004 - Centrum Medyczne Lucyna Andrazej Dymek - Strzelce Opolskie; 🇵🇱 Strzelce Opolskie, Poland

Site 616003 - Lekarze Specjalisci - J. Malolepszy i Partnerzy; 🇵🇱 Wrocław, Poland

Site 616012 - Centrum Badan Klinicznych Piotr Napora Lekarze Spolka Partnerska, Centrum Badan Klinicznych Osrodek Badan Wczesnej Fazy; 🇵🇱 Wrocław, Poland

Site 616009 - Samodzielny Publiczny Zaklad Opieki Zdrowotnej Uniwersytecki Szpital Kliniczny Nr 1 im. Norberta Barlickiego Uniwersytetu Medycznego w Lodzi; 🇵🇱 Łódź, Poland

Site 642004 - Clinical Hospital Of Pneumology Leon Daniello; 🇷🇴 Cluj-Napoca, Romania

Site 642007 - ICRH Prof DR Octavian Fodor, Sectia Medicina Interna si Ambulator Alergologie; 🇷🇴 Cluj-Napoca, Romania

Site 642003 - Spitalul De Boli Infectioase Victor Babes, Craiova; 🇷🇴 Craiova, Romania

Site 616021 -IP Clinic Sp. z o.o.; 🇵🇱 Łódź, Poland

Site 642005 - Angisan grup srl; 🇷🇴 Bragadiru, Romania

Site 642001 6 Centrul Medical de Diagnostic si Tratament Neomed; 🇷🇴 Brasov, Romania

Site 642002 - Institute of Pneumology 'Marius Nasta'; 🇷🇴 Bucuresti, Romania

Site 642008 - SPITALUL CLINIC DE PNEUMOFTIZIOLOGIE IASI, Sectia Clinica I de Pneumologie; 🇷🇴 Iasi, Romania

Site 642006 - Fundatia Cardioprevent; 🇷🇴 Timisoara, Romania

Site 642009 - Spitalul Clinic de Boli Infectioase si Pneumoftiziologie Dr. Victor Babes; 🇷🇴 Timisoara, Romania

Site 710013 - Office of Dr. Agatha Cathrine Wilhase, MD; 🇿🇦 Boksburg, South Africa

Site 710005 - Worthwhile Clinical Trials; 🇿🇦 Benoni, South Africa

Site 710003 - Office of Dr. ZFA Vawda MD; 🇿🇦 Durban, South Africa

Site 710012 - CRISMO Research Centre; 🇿🇦 Germiston, South Africa

Site 710015 - University Of The Witwatersrand; 🇿🇦 Johannesburg, South Africa

Site 710004 - Synapta Clinical Research Center; 🇿🇦 Durban, South Africa

Site 710006 - Langeberg Medicross Medical Centre; 🇿🇦 Kraaifontein, South Africa

Site 710007 - Ubuntu Clinical Research; 🇿🇦 Lenasia, South Africa

Site 710001 - Emmed Research- Jakaranda Hospital; 🇿🇦 Pretoria, South Africa

Site 710002 - Lenmed- Ahmed Kathrada Private Hospital; 🇿🇦 Lenasia, South Africa

Site 710009 - Global Clinical Trials; 🇿🇦 Pretoria, South Africa

Site 710011 - Busamed Paardevlei Hospital; 🇿🇦 Somerset West, South Africa

Site 710014 - University Of Stellenbosch; 🇿🇦 Stellenbosch, South Africa

Site 724005 - Clinica Mi Tres Torres Barcelona; 🇪🇸 Barcelona, Spain

Site 710010 - Limpopo Clinical Research Initiative; 🇿🇦 Thabazimbi, South Africa

Site 710008 - Welkom Clinical Trial Centre; 🇿🇦 Welkom, South Africa

Site 724008 - Hospital del SAS de Jerez de la Frontera; 🇪🇸 Jerez De La Frontera, Spain

Site 724002 - Servicio Andaluz de Salud Consejeria de Salud - Hospital Universitario Virgen de la Victoria; 🇪🇸 Málaga, Spain

Site 724004 - Hospital Universitario Marqués de Valdecilla; 🇪🇸 Santander, Spain

Site 724006 - Complejo Hospitalario Universitario De Santiago; 🇪🇸 Santiago De Compostela, Spain

Site 724003 - Hospital La Plana; 🇪🇸 Vila-Real, Spain

Site 724001 - Hospital Universitario Miguel Servet; 🇪🇸 Zaragoza, Spain

Site 724007 - Hospital General Universitario Gregorio Maranon (HGUGM); 🇪🇸 Madrid, Spain

Site 724007 - Hospital General Universitario Gregorio Maranon (HGUGM) - Instituto de Investigacion Sanitaria Gregorio Maranon (IiSGM); 🇪🇸 Madrid, Spain

Site 410001 - Konkuk University Medical Center; 🇰🇷 Seoul, Korea, Republic of

Site 410002 - The Catholic University of Korea, Seoul St. Marys Hospital; 🇰🇷 Seoul, Korea, Republic of

Site 410005 - Korea University Guro Hospital; 🇰🇷 Seoul, Korea, Republic of

Site 410006 - Asan Medical Center (AMC); 🇰🇷 Seoul, Korea, Republic of

Site 410008 - Severance Hospital, Yonsei University Health System; 🇰🇷 Seoul, Korea, Republic of