ACTRN12618000089235
Recruiting
未知
A randomised controlled trial of nitric oxide administration during cardiopulmonary bypass in neonates undergoing Arterial Switch Operation for repair of transposition of the great arteries to evaluate an effect on major adverse events (death, ECMO, cardiac arrest)
Christopher James0 sites800 target enrollmentJanuary 19, 2018
Overview
- Phase
- 未知
- Intervention
- Not specified
- Conditions
- congenital heart disease
- Sponsor
- Christopher James
- Enrollment
- 800
- Status
- Recruiting
- Last Updated
- 4 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Neonate diagnosed with TGA requiring Arterial Switch Operation
- •Consent of parents/guardian.
Exclusion Criteria
- •Signs of persistently elevated pulmonary vascular resistance preoperatively requiring iNO or preoperative use of drugs involved in the NO pathway, such as nitro\-glycerine, sildenafil
- •Requirement for ECLS prior to surgery
- •Concurrent viral or bacterial acute or chronic infection, including pulmonary conditions such as pneumonia
- •Pre\-operative acute respiratory distress syndrome
- •Cardiac arrest prior to surgery
- •Prior surgical exposure to cardio\-pulmonary bypass
Outcomes
Primary Outcomes
Not specified
Similar Trials
Completed
Phase 2
A randomized controlled trial on the use of Nitrous oxide versus conventional intravenous pain relief in minor gynecological proceduresanalgesic efficacy of the patient controlled inhaled Nitrous oxide with intravenous opioids (Pethidine &Midazolam) in reducing pain during minor gynecological operative procedure, including MVA, fractional curettage and dilatation and curettageNitrous oxide, Manual vacuum aspiration, Dilatation and curettage, Midazolam, PethidineTCTR20230107003Endowment fund, Faculty of Medicine, Chiang Mai University106
Completed
Not Applicable
Safety and efficacy study of a nitric oxide generating system for neonatal cannulatioeonatal Diseases: CannulationNeonatal DiseasesCannulationISRCTN96341949Record Provided by the NHSTCT Register - 2004 Update - Department of Health (UK)
Completed
Phase 3
Randomized Trial of Inhaled Nitric Oxide to Augment Tissue Perfusion in SepsisSepsisNCT00608322National Institute of General Medical Sciences (NIGMS)49
Completed
Phase 2
A Study on the Safety and Efficacy of Nitric Oxide Gel in Subjects With Painful Diabetic NeuropathyNeuropathic PainNCT01633086China Medical University Hospital24
Recruiting
Phase 3
A randomized controlled trial of continuous nitroglycerine Infusion with or without a preceding nitroglycerine bolus dose in older patients with acute heart failure.itroglycerine bolus dose and follow by in fusion in emergency department older adults with hypertensive heart failure.Nitroglycerine, older adults, hypertension, heart failureTCTR20230517007avamindradhiraj University Research Fund186