Comparing Opioid Free Versus Opioid Balanced Anesthesia in Ophthalmic Surgery: a Single Centre Randomized Controlled Trial
Overview
- Phase
- Phase 2
- Intervention
- Fentanyl
- Conditions
- Anesthesia and Analgesia
- Sponsor
- Indonesia University
- Enrollment
- 104
- Primary Endpoint
- Postoperative nausea and vomiting (PONV)
- Status
- Not yet recruiting
- Last Updated
- 2 years ago
Overview
Brief Summary
Anesthesia without the use of opioid (Opioid free anesthesia) is an alternative to conventional opioid balanced anesthesia, with less post operative nausea and vomiting, and comparable analgesia. This study aim to compare the effect of opioid free versus opioid balanced anesthesia in ophthalmology surgery
Investigators
Aida Rosita Tantri
Anesthesiologist
Indonesia University
Eligibility Criteria
Inclusion Criteria
- •Physical status of ASA 1-2
- •Undergo elective ophthalmology surgery under general anesthesia with laryngeal mask insertion
- •BMI 17.5-34.9
Exclusion Criteria
- •Allergy to study drugs
- •Baseline heart rate \< 70 beat per minute or systolic blood pressure \< 100 mmHg
- •Will undergo regional block
- •Operation lasting for \> 4 hours or \< 90 minutes
- •Consumes opioid routinely prior to operation
Arms & Interventions
Control
Intervention: Fentanyl
Opioid free anesthesia
Intervention: Dexmedetomidine
Outcomes
Primary Outcomes
Postoperative nausea and vomiting (PONV)
Time Frame: 24 hours
Incidence of PONV
Time to laryngeal mask exertion
Time Frame: Intraoperative
Measured from the last surgical knot to LMA exertion
Adverse effect
Time Frame: 24 hours
Severe changes in hemodynamics, including severe bradycardia, tachycardia, hypotension, hypertension, desaturation
Pain score
Time Frame: 24 hours
Pain score assessed with numerical rating scale (0-10) where higher value corresponds to more pain experienced by the patient